SINGAPORE, July 16, 2024 /PRNewswire/ — Biosyngen, a leading biotechnology company focused on the development of innovative cell therapies, recently announced that the Center for Drug Evaluation (CDE) of the National Medical Products Administration (NMPA) in China has approved the initiation of a pivotal Phase ll clinical trial evaluating BRG01, the company’s autologous Epstein-Barr virus (EBV) specific chimeric antigen receptor T-cell (CAR-T) therapy, for the treatment of patients with recurrent or metastatic EBV-positive nasopharyngeal carcinoma. BRG01 is the world’s first CAR-T therapy for solid tumor to obtain clinical trial approvals from China and the U.S. and to advance to a pivotal Phase ll clinical trial, representing a significant milestone in the field of cell-based immuno-therapies for solid cancers.
“The approval of the Phase ll clinical trial for BRG01 is a testament to the robust preclinical data and strong early clinical results observed with this innovative therapy” said Professor Zhang Li, Director of the Phase l Ward at the Sun Yat-Sen University Cancer Center and Deputy Director of the Lung Cancer Research Institute at Sun Yat-sen University, who is serving as the principal investigator for the BRG01 clinical trial. “BRG01 has the potential to be a first-in-class T-cell therapy for EBV-positive tumors, and we are confident in its ability to deliver meaningful clinical benefits to patients with this difficult-to-treat malignancy.”
Professor Zhang Li
The Phase l clinical trial of BRG01 in China and the U.S. has completed patient enrollment in January this year. All participants have received BRG01 infusion as part of this registered clinical trial. The Phase l study has successfully completed assessments of dose-limiting toxicity (DLT) and preliminary efficacy in nine patientswith advanced nasopharyngeal carcinoma who had previously been treated with at least one immune checkpoint inhibitor, such as a PD-1antibody.
Initial data from the study have demonstrated excellent safety and encouraging signs of clinical activity, with 75% of high-dose patients experiencing local tumor shrinkage and reduced metabolic activity on PET-CT scans, and some patients achieving complete remission of their tumor lesions. Additionally, BRG01 has shown potent anti-EBV activity, with significant reductions in peripheral blood EBV viral load observed following treatment.
These findings underscore BRG01’s potential in tumor therapy and highlight its dual benefits in antiviral treatment, establishing a robust foundation for future clinical applications. These results are likely pivotal in the CDE’s decision to advance BRG01 to phase II clinical trials.
BRG01 is an autologous T cell immunotherapy product that has been engineered to express chimeric receptors targeting the Epstein-Barr virus (EBV) antigen on the surface of T cells. This innovative therapy represents a new generation of CAR-T cell treatment specifically designed to target EBV. BRG01 received phase I clinical trial approval from the CDE in China in December 2022 and from the FDA in the United States in February 2023. Subsequently, it was granted orphan drug designation (ODD) and fast track designation (FTD) by the FDA in June and July 2023, respectively.
At the annual Meeting of the American Society of Gene and Cell Therapy (ASGCT) in May, Biosyngen presented preclinical research on the therapy, and the data was published as an original study in Frontiers in lmmunology. In addition, at the Gordon Research Conference (GRC) on Nasopharyngeal Carcinoma held in Switzerland in early June this year, Biosyngen’s scientist and pipeline inventor, Chair of Translational Immuno-Oncology at the University of Cologne, Professor Renata Stripecke also presented the results of preclinical research and the latest clinical data of this therapy.
The development of cell therapy drugs for hematological malignancies has seen substantial progress, yet advancements in solid tumor treatments have lagged behind. The FDA’s accelerated approval of lovance’s tumor-infiltrating lymphocyte (TlL) therapy, lifileucel, for the treatment of advanced melanoma in February represents a significant milestone in the commercialization of solid tumor cell therapies. This milestone has bolstered confidence among companies engaged in the development of cell therapies for solid tumors. However, overcoming the challenges posed by solid tumors requires a unique and comprehensive approach from the outset. This approach must encompass considerations regarding technology, target selection, and indication, ensuring satisfaction of clinical needs and druggability of the therapeutic interventions.
As one of the most common head and neck tumors, nasopharyngeal carcinoma – an epithelial carcinoma arising from the nasopharyngeal mucosal lining, is closely related to EBV infection. According to WHO, an estimated number of 133,000 new cases of nasopharyngeal carcinoma worldwide was reported in 2020; 50% of which was diagnosed in China. South China provinces such as Guangdong and Guangxi provinces make up for more than 60% of nasopharyngeal carcinoma patient population in China. Though existing practice such as immune checkpoint inhibitor has been applied in second-line treatment of nasopharyngeal carcinoma, overall response rates were generally below 30%. In another words, more than 70% patients did not benefit from existing therapy. Therefore, it is imperative to explore new approaches to improve efficacy and satisfy unmet medical needs.
The emergence and progression of nasopharyngeal carcinoma are closely associated with Epstein-Barr virus (EBV) infection. EBV has infected about 95% of population worldwide. It has been listed as Group 1 carcinogen (“Carcinogenic to humans”) by World Health Organization (WHO) and proved to be associated with a range of diseases including nasopharyngeal carcinoma, EBV-positive gastric cancers, lymphoma and lymphoproliferative diseases. Research indicates that tumor cells in nasopharyngeal carcinoma frequently exhibit EBV antigen expression, and EBV-positive tumor cells display target proteins for CD4+T cells and CD8+T cells, facilitating the infiltration of EBV-targeting CAR T cells into tumor tissue to exert a cytotoxic effect.
Leveraging this specific EBV target, CAR T-cell therapy developed by Biosyngen is also being explored for treating EBV-positive lymphoma. In April 2023, BRG01 obtained approval from the Drug Evaluation Center (CDE) and the Food and Drug Administration (FDA) for clinical trials in this new indication, with Phase I clinical studies currently ongoing.
Biosyngen has evolved into a biotechnology company specializing in three major cell therapies for solid tumors and hematologic malignancies, including CAR-T, TCR-T, and TIL. The company’s therapies utilizing these strategies have all been granted approvals for clinical trials, with its TCR-T and TIL therapies targeting various solid tumors such as lung and liver cancer.
“The approval of BRG01 for a pivotal Phase ll clinical trial is a major milestone for Biosyngen and underscores our commitment to developing innovative cell therapies to address significant unmet needs in solid tumors,” said Dr. Michelle Chen, Co-Founder and CEO of Biosyngen. “We plan to continue investing in research and development to expedite the clinical progress and market availability of BRG01, offering more effective treatment options for patients worldwide.”
With Biosyngen’s efficient operations and rapid research outcomes, there is optimism for significant advancements in solid tumor cell therapies within a shorter timeframe, potentially bringing new treatment possibilities and hope to patients.
KUALA LUMPUR, Malaysia, July 15, 2024 /PRNewswire/ — The National Art Gallery inaugurated the “Rantau: IMT-GT Exhibition”, which will be exhibited from today until 1st December 2024. This exhibition is held in conjunction with the Visit Year of the Indonesia-Malaysia-Thailand Growth Triangle 2023- 2025, also known as IMT-GT 2023-2025. The inauguration was officiated by YBrs. Mr. Shaik Rizal Sulaiman, Chairman of the National Visual Arts Development Board (NVADB), at the National Art Gallery.
Art performance by the collective group Rumah Ada Seni from Indonesia in front of their work titled “Garobak Galeri” during the opening of the IMT-GT: Rantau Exhibition.
This exhibition is an artistic expression by visual artists from three countries, portraying thoughts and feelings about nature, family relationships, life struggles, past stories, survival, daily routines, and everyday life. The collaboration of the three countries through this exhibition celebrates togetherness, regional unity and cultural diversity.
The “Rantau: IMT-GT Exhibition” involves the participation of five curators, two art collectives, four solo artists and two artist duos. Indonesiais represented by guest curator Bayu Genia Krishbie from Galeri Nasional Indonesia, together with Rumah Ada Seni, an art collective from Padang, West Sumatrawith nine members led by Yusuf Fadly Aser; Sikukeluang Collective from Pekan Baru, Riau, a transdisciplinary collective with six members led by Adhari Donora; and Arifa Safura and DJ Rencong duo from Acheh.
Malaysiais represented by curators Faridah Hanim Abd Wahab and Adina Quraisa Ibrahim, along with the guest writer Liu Cheng Hua, artists Chong Yan Chuah, Khairul Izzudin and Shamin Sahrum, who have backgrounds in architecture and large-scale works. Their works are related to the theme of Rantau as well as to their own experiences in relation to ‘merantau‘ (travelling).
Thailandis represented by Suebsang Sangwachirapiban, a curator from the Bangkok Art Biennale, along with artists Nordiana Beehing from Yala, Maneerat Thamnarak from Chumphon and Arichama Pakapet from Songkhla.
They play a role in initiating artistic dialogues and building relationships in their communities, helping to harness the benefits of the economic and sociocultural development in the region under the umbrella of the IMT-GT.
The inauguration ceremony was also attended by YBrs. Mr. Amerrudin Ahmad, Director General of the National Art Gallery; YBrs. Mr. Bukhairi Bakhtiar, Director of Centre for Indonesia-Malaysia-Thailand Growth Triangle (IMT-GT) Subregional Cooperation; representatives from the embassies of Indonesia and Thailand in Malaysia; officers from MOTAC and agencies; as well as art enthusiasts.
The “Rantau: IMT-GT Exhibition” highlights the National Art Gallery’s ongoing commitment to supporting regional art development, strengthening international relations, and promoting the tourism sector’s advancement.
Therefore, the public is invited to appreciate the spirit of togetherness and celebrate cultural diversity through the “Rantau: IMT-GT Exhibition” at the National Art Gallery until 1st December 2024. Admission is free. For more information, visit www.artgallery.gov.my and the National Art Gallery’s official social media.
Ring the alarm: Prime Day is nearly here! While you put the finishing touches on your wishlist, we’ll fill you in on a little secret: Amazon isn’t the only retailer that’s having a major sale. You can score plenty of deals on kitchen essentials, fab finds for your wardrobe and shiny new tech, thanks to heavy hitters like Walmart, Adidas, Best Buy, Coach, Target, Samsung, Dyson, Kate Spade and more getting in on the action.
Don’t know where to get started? Worry not — you’re in good hands. We vet every single deal by running it through price trackers, reading thousands of reviews and checking in with our own roster of experts to determine the very best goodies to spend your hard-earned cash on. Consider us your shopping fairy godparents.
Our first tip: Keep checking this page, and often. We’ll be updating it throughout Amazon Prime Day 1 and 2 and adding in the best deals we spot from across the web (though if you want some brownie points, you should also check out our guide to all things Amazon Prime Day). No Prime Day FOMO for you!
Table of contents
Best Prime Day kitchen deals
There’s no better time to upgrade those dull knives and caked-on cookware (and maybe finally get your hands on that one contraption that’s sure to make breakfast a snap). Save big on sought-after brands like Ninja, Hamilton Beach and more.
Amazon
Just add ingredients to each nonstick pan, close the device, wait about five minutes and remove the layers to stack the sandwiches. Breakfast for two is served!
Don’t sweat over a hot stove in the hot weather. The bestselling Ninja air-fries, roasts, bakes, reheats and dehydrates right on your counter, and it’s nearly 40% off.
Amazon: While there’s certainly no shortage of deals on just about anything you might have on your culinary wishlist, make sure you don’t miss out on the No. 1 bestselling Instant Pot Duo 9-in-1 being marked down 42%, and the über-popular Hamilton Beach Dual Breakfast Sandwich Maker is at its lowest price in years (and the lowest price on the web).
Le Creuset: The factory to table sale is on! Snag select items from the brand beloved by everyone from Ina Garten to Jennifer Garner for up to 40% off, plus get free shipping on all orders over $99.
Our Place: Celebs like Selena Gomez and Oprah are fans of this aesthetically pleasing, PFAS-free cookware, and you can snag the bestselling Always Pan for a rare $105 during the brand’s Summer Sale.
Walmart: We spotted savings on tons of Ninja appliances, including an air fryer for just $69 (down from $89) and a woodfire grill for just $249 (was $298).
Best Prime Day bedding and mattress deals
A quality mattress is a worthy investment, and now is the time to save a few bucks on one. Big sales events are the best times to buy, whether you’re in the market for memory foam, a hybrid model or a cooling mattress that’ll keep night sweats at bay. And while you’re at it, why not stock up on some new sheet sets or some plush new pillows?
Amazon
Not only do these ultra-soft sheets have over 247,000 5-star reviews, but they’ve also earned the stamp of approval from Yahoo editor Janelle Randazza, who compares them to her beloved Cozy Earth set.
“They are the kind of soft that feels most often reserved for kids’ pajamas,” she reported.
If there was a popularity contest for mattresses, the Casper One just might win. The ultra-popular model is made with three layers of breathable memory foam that cradles your body throughout the night and provides support where you need it most.
If you don’t want to splurge on a luxe memory foam mattress, this one is a great option for a guest bed or if you’re on a budget. It doesn’t skimp on quality, either: layers of supportive foam cradle you throughout the night, plus each layer is infused with calming green tea.
Amazon: Looking for some new sheets? What about a whole new mattress? No matter your need, Amazon has you covered with some Prime Day steals.
Brooklinen: Score the dreamy linen brand’s sale items for up to 50% off, including gorgeous sateen pillowcases and duvet covers. Plus, first-time shoppers get 15% off their order sitewide.
Buffy: Enjoy sitewide savings of up to 20%, including the brand’s beloved temperature-regulating comforters and sheets.
Casper: Save up to 30% off everything from the brand’s rigorously tested catalog — like its popular hybrid and cooling mattresses.
Cozy Earth: The brand that graced Oprah’s Favorite Things list five times in a row is offering up to 25% off its luxurious bedding, pajamas and more. If Oprah approves, you know it’s good!
Purple: Don’t snooze on the brand’s back to school sale, where you can score up to 50% off a complete sleep bundle, which includes a sheet set, two Purple Cloud pillows, a mattress protector and the PurpleFlex Mattress. The mattress is made using the patented GelFlex Grid, which adapts to support your movements while you sleep.
Serta: Save up to $600 on all three Serta iComfortEco mattresses, which are made with up to 70% sustainable materials.
Walmart: Trade your old bedding for a bestselling sheet set marked down by 60% ($17, down from $63), plus get a popular pair of Serta cooling pillows for $23 (down from $40).
Best Prime Day beauty deals
Amazon
This top-selling serum, made with 96.3% snail secretion filtrate, may sound bizarre and even medieval, but loads of reviewers say it helps improve dullness and dryness. The serum’s lightweight formula absorbs quickly and doesn’t leave a film or feel heavy on the skin. It’s hypoallergenic and free of any artificial fragrances too.
This mild retinol is filled with skin-calming agents like niacinamide and moisturizing hyaluronic acid. Best of all, it’s now at one of the lowest prices our price trackers have seen, so it’s inexpensive enough to try without the guilt of a major skin-care investment.
Sephora: The beauty retailer is offering discounts on select makeup, hair care, skin care and more in their sale section, including a Dyson straightener for $100 off.
Walmart: The retail giant is notorious for its irresistible markdowns, so get ready to fill your cart with fragrances, beauty tools and more at a savings.
Best Prime Day home deals
Home is where the savings are — at least, it is now. From cleaning essentials like stick vacs (like the ever-elusive on-sale Dyson) to warm weather must-haves like portable A/Cs, outdoor furniture and dehumidifiers, these are the most worthwhile products for making your summertime livin’ easy — and at wallet-friendly prices.
Dyson
This lightweight stick vac detangles hair as it cleans, so you won’t be left picking out strands from its brush. It also quickly transforms into a handheld for your car and stairs. You can even lift it up over your head to clean the top of cabinets and ceiling fans in one smooth motion.
Wayfair: Score a stunning new carpet for up to 60% off during the retailer’s Rug Sale. Don’t miss the dozens of washable options.
Best Prime Day style deals
Whether you’re still fleshing out your summer wardrobe or are already looking forward to autumn, there are plenty of stylish deals to go around — from Coach and Kate Spade bags to Nike sneakers and even Lululemon leggings, you’ll be dressed to the nines this season (and no one has to know you didn’t pay full price).
Amazon
These No. 1 bestselling slip-on sneaks are an unexpected celeb favorite (Martha Stewart is a fan!) and don’t often go on sale — so we suggest snapping them up now. The pillowy shoes have a lightweight cushioned midsole and a removable insole that’s podiatrist-certified, so you know you’ll get the support you need.
These slimming leggings are a steal even at full price — but nabbing them at under $20 is practically criminal. They have pockets large enough to fit your phone, plus the crop ensures they won’t awkwardly bunch around your ankles. Plus, with nearly 38,000 reviews, you’re sure to be in good company.
J.Crew Factory: The deals are always fab at J.Crew Factory, but they’ve somehow gotten even better with up to 60% off everything. Don’t miss the sale section, where you can also pick up an extra 60% off already marked-down styles.
Kate Spade: If you’ve had your eye on the brand’s chic crossbody bags and classic totes, you can now scoop them for up to 50% off. We have our eyes on this equestrian-inspired style, marked down to $295 (was $378).
Kate Spade Outlet: Summertime and the saving is easy at KSO: Grab an extra 20% off over 350+ styles.
Lululemon: Cute crop leggings for nearly $30 off, running shoes on markdown and more deals abound in the brand’s “We Made Too Much” section.
Madewell: It’s definitely worth swinging by Madewell’s sale section, with up to 70% off summer essentials like comfy V-necks and swishy sundresses. Plus, everything that’s already marked down gets an extra 30% off (and 50% off for denim) with code COOLDOWN.
Nike: Run away with up to 40% off sale items, and get an extra 25% off with code EXTRA25 — plus, free shipping on orders over $50 for members.
REI: Outdoorsy folks can nab up to 50% off clothing and footwear. We’re talking top-rated North Face joggers ($49, was $70), Hoka hiking boots for $138 (down from $185), and oodles more.
Tory Burch: Grab a Tory Burch fan-favorite bag on sale — prices start at $159.
Walmart: From 80% off select jewelry to swimwear, sundresses and more at deep discounts, Walmart is, as always, a powerhouse of sizzling savings this summer.
Best Prime Day headphones, earbuds and speaker deals
Searching for sweat-resistant new buds for the gym? Perhaps you’re on the hunt for oversized cans to block out your snoring neighbor on your next flight. Either way, you can enjoy your fave podcasts, and music (or better yet, the sweet sound of silence) for a song.
Amazon
The ever-popular AirPods with more than 543,000 flawless ratings are on sale for just $80, a markdown of nearly 40%. Find out why so many people swear by these buds and their hours of battery life, one-touch setup, and more.
Apple: Apple is in the middle of their Back to School blowout, but if you don’t find what you want on their website, make sure to check other retailers — we’re seeing great savings on everything from AirPods to Macs.
Best Buy: We’re seeing tons of discounts on waterproof Bluetooth speakers that are perfect for the beach, as well as high-end headphones like Beats Studio Pros.
Target: Score up to 30% off earbuds or grab a pair of headphones starting from just $10.
Walmart: Walmart has discounts of as much as 80% off select brands of earbuds, but you can also find fantastic deals on sound bars, Bluetooth speakers, and more.
Best Prime Day TV deals
If you’ve been holding out on finally getting your hands on a gorgeous new screen, wait no longer — you can grab a spectacular set from big brands like Samsung, TCL, Insignia and more.
Amazon
Sure, it might be on the smaller side, but if you need a TV for your garage or a smaller bedroom, this is a great pick. You have access to full Alexa functionality through the Alexa Voice Remote, which means you can change channels, search for content and more just by yapping. Plus, this is on par with its lowest price ever.
A 75-inch TV for under $500? No, Walmart didn’t make a typo; you can score this gorgeous 4K screen for over $400 off. If you’ve spent the past year squinting at your TV screen, it’s time to splurge on something bigger and better. Plus, this is currently the lowest price we spotted on the web.
Amazon: Fire TVs are having their moment at the retailer’s Prime Day sale, with smart sets starting at just $65.
Best Buy: You can save as much as $2,500 on a brand-new 100-inch TV from Best Buy. Looking to make that home theater splurge a little more affordable? Now’s your chance.
Samsung: Save as much as $3,500 on a Samsung Terrace outdoor TV, and snag major savings across a broad range of other options, including the Samsung Frame lineup.
It’s way too hot to go outside (unless you’re going from one air-conditioned space to another). Need some entertainment? These tablets and laptops will deliver just that in spades.
Amazon
This lightweight powerhouse boasts enough storage and RAM to tackle almost any project you can throw at it. Its operating system lets you seamlessly transition between iPhone, iPad and MacBook, and you can snag this one in four different colors. Did we mention this is the lowest price we’ve spotted on this model?
Meet Amazon’s most powerful tablet ever, with 14 hours of battery life and a huge display that makes it just the ticket for everything from watching content to gaming. At nearly 40% off, it’s at the lowest price we’ve seen.
Jason Liberty, Royal Caribbean Cruises president and CEO, joins ‘Squawk on the Street’ to discuss how Trump’s assassination attempt could impact business, why Royal Caribbean’s ‘Utopia of the Seas’ is important to the brand, and much more.
Don’t miss exclusive deals for one of America’s top robotic lawn mowers
HONG KONG, July 15, 2024 /PRNewswire/ — MAMMOTION is ready to transform backyards across America with exclusive Prime Day deals and summer savings. From July 16-17, customers can enjoy up to $600 off the cutting-edge LUBA 2 AWD 5000, and each order will include a $39 value sticker for free. MAMMOTION is also offering additional deals across the LUBA 2 AWD Series available on MAMMOTION online store,Amazon, and Walmart.
Celebrate Summer with MAMMOTION’s Prime Day and Lawn Season Deals: Up to $600 off on LUBA 2 AWD Lawn Mowers
Picture yourself relaxing on the porch while the LUBA 2 AWD 5000 takes care of your lawn. This smart mower acts as your personal groundskeeper, making lawn maintenance easy and precise:
Fearless on 80% slopes: While you’re relaxing, it’s scaling hills that would make mountain goats nervous.
Brain meets brawn: 3D Vision Positioning and RTK Fusion-mapping ensure it trims every blade with precision.
Customization king: Multi-zone management and app control let you personalize your lawn care down to the millimeter.
Lawn artist: Transform your grass into a canvas with the unique lawn printing function.
But the savings don’t stop there. MAMMOTION is extending discounts for its LUBA 2 AWD lineup across the MAMMOTION online store, Amazon, and Walmart:
LUBA 2 AWD 10000: Now $3,649 (11% off, save $450)
LUBA 2 AWD 5000: Now $2,299 (20.7% off, save $600)
LUBA 2 AWD 3000: Now $2,249 (10% off, save $250)
LUBA 2 AWD 10000H: Now $3,799 (7.30% off, save $300)
LUBA 2 AWD 5000H: Now $2,599 (10.30% off, save $300)
LUBA 2 AWD 3000H: Now $2,249 (10% off, save $250)
“These Prime Day and summer discounts make it easier for everyone to upgrade their lawn care,” says Jidong Wei, CEO of MAMMOTION. “Our LUBA 2 AWD series lawn mowers offer top-notch performance and convenience, giving you more time to enjoy your outdoor space. We’re excited to offer these savings to help more people experience the benefits of robotic mowing.”
MAMMOTION’s LUBA 2 AWD Series is designed to tackle a variety of lawn sizes and terrains, offering features like app control, customizable schedules, and efficient mowing patterns. By automating lawn maintenance, these mowers aim to provide consistently well-maintained lawns while freeing up time to enjoy the outdoors.
About MAMMOTION MAMMOTION is dedicated to cultivating an intelligent and high-quality eco-friendly outdoor lifestyle through innovative robotic solutions. Our mission commences with revolutionizing robot lawn mowers for both professionals and consumers, paving the way for a more sustainable and efficient outdoor experience.
ROCKVILLE, Md., July 15, 2024 /PRNewswire/ — I-Mab (NASDAQ: IMAB) (the “Company” or “I-Mab”), a U.S.-based, global biotech company, announced today that the Board of Directors of the Company has appointed Mr. Wei Fu as the Chairman of the Board of Directors. He succeeds Dr. Pamela M. Klein, who steps down from I-Mab’s Board of Directors and the Interim Chairperson position. Mr. Wei Fu has served as a member of the I-Mab Board of Directors since June 2018 and is the Chief Executive Officer of CBC Group, a healthcare asset management firm and the founding and largest shareholder of I-Mab.
In addition, Mr. Raj Kannan intends to leave his role as Chief Executive Officer and as a member of the Company’s Board of Directors, effective July 15, 2024. Mr. Kannan will stay as an advisor of the Company until July 31, 2024 to assist with the transition. This decision follows a mutual agreement with the Board of Directors. Dr. Sean Xi-Yong Fu has assumed the role of Interim Chief Executive Officer and a member of the Board of Directors, effective July 15, 2024.
In addition to being Interim CEO and Director of I-Mab, Dr. Sean Fu is also an Operating Partner of ABio-X, an incubation platform for life sciences companies. Before joining ABio-X, Dr. Fu was co-founder and CEO of RVAC Medicines, an mRNA platform company. Prior to founding RVAC, Dr. Fu was Group VP and head of International R&D for Luye Pharma, overseeing organizations in Boston, Princeton, Germany, Switzerland and Japan. He was also the CEO of GeneLeap, a Luye subsidiary company focused on DNA and RNA therapeutics. Previously, Dr. Fu worked at Merck & Co. for 15 years with responsibilities covering R&D, business development, finance and operational management. His work at Merck included management of the finances for the late-stage clinical portfolio and leading the integration of global R&D network following the landmark $42 billion merger between Merck and Schering-Plough. Dr. Fu earned a Master’s and PhD degrees in materials science and engineering from Ohio State University, and an MBA from the Wharton School of University of Pennsylvania.
“Our dedication to scientific innovation and to our strategic objectives for bringing life-changing drugs to market is unwavering,” said Mr. Wei Fu, I-Mab’s new Chairman. “I am confident Dr. Fu will provide invaluable leadership for our talented team in advancing our innovative R&D pipeline and our business in his role as Interim CEO. He brings a wealth of biotech industry experience and relationships to support the Board as we secure the best permanent leader to take I-Mab forward and drive our growth opportunities and value for shareholders. Meanwhile, we’d like to extend our gratitude to Ms. Klein and Mr. Kannan for their support and contributions to I-Mab.”
“I’m grateful for this opportunity and excited to lead I-Mab. During this pivotal time, I am dedicated to leading I-Mab through the completion of its transformation to becoming a U.S.-based biotech company, to build the Company’s highly differentiated pipeline, and work with our Board of Directors, leadership team and talented employees and partners to create new treatment options for patients around the world,” said Dr. Sean Fu, Interim CEO of I-Mab.
In addition to these leadership transitions, the Company also announced certain changes to the composition of the Board of Directors and its committees:
the resignations of Dr. Ruyi He and Professor Rong Shao as Directors, and
the appointments of Mr. Wei Fu and Mr. Conor Chia-hung Yang as new members of the compensation committee with Mr. Wei Fu being the Chairman thereof, and Mr. Sean Xi-Yong Fu as a new member of the ESG committee.
After the transitions, the Company’s Board of Directors will consist of Mr. Wei Fu (Chairman), Dr. Sean Xi-Yong Fu, Mr. Chun Kwok Alan Au, Mr. Conor Chia-hung Yang, and Mr. Shuai Chen. The Company’s audit committee will consist of Mr. Yang (Chairman), Mr. Au, and Mr. Chen. The Company’s nominating and corporate governance committee consists of Mr. Wei Fu (Chairman), Mr. Au, and Mr. Yang. The compensation committee will consist of Mr. Wei Fu (Chairman), Mr. Au, and Mr. Yang, and the ESG committee will consist of Mr. Au (Chairman) and Mr. Sean Xi-Yong Fu.
About I-MAB
I-Mab (NASDAQ: IMAB) is a U.S.-based, global biotech company, exclusively focused on the development and potential commercialization of highly differentiated immunotherapies for the treatment of cancer.
I-Mab has established operations in the U.S. in Rockville, Maryland, and in San Diego, California. For more information, please visit https://www.i-mabbiopharma.com and follow us on LinkedIn and X.
Forward Looking Statements
This press release contains forward-looking statements. These statements are made under the “safe harbor” provisions of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements can be identified by terminology such as “will”, “believes”, “dedication”, “objectives”, “intends”, “potential”, “determined to”, and similar terms or the negative thereof. Forward-looking statements are based on I-Mab’s current expectations and assumptions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks, and changes in circumstances that may differ materially from those contemplated by the forward-looking statements, which are neither statements of historical fact nor guarantees or assurances of future performance. Important factors that could cause actual results to differ materially from those in the forward-looking statements are set forth in filings with the U.S. Securities and Exchange Commission. I-Mab undertakes no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as may be required by law.
I-Mab Contacts
Investors & Media Tyler Ehler Senior Director, Investor Relations IR@imabbio.com
BEIJING, July 15, 2024 /PRNewswire/ — China Media Group, Esports World Cup Foundation and VSPO have signed a strategic cooperation agreement on Friday as the new China Media Group National Institute for Esports Development kicked off in Beijing.
China Media Group (CMG), which operates state television networks including CCTV, formally unveiled the new CMG National Institute for Esports Development on Friday. The Institute then signed a strategic cooperation agreement with the Esports World Cup Federation and VSPO during the establishment ceremony, vowing to jointly organize and participate in future esports events.
The three organizations have been long-time advocates for the healthy development of the esports industry. VSPO already works with the Esports World Cup Foundation in organizing the inaugural Esports World Cup, an eight-week mega event currently underway in Riyadh with a record-breaking prize pool of more than $60 million.
The three parties have been longtime proponents of the healthy development of the esports industry. VSPO already works with the Esports World Cup Foundation in organizing the inaugural Esports World Cup currently underway in Riyadh, an eight-week mega event with a record-breaking prize pool of more than $60 million.
“It’s a huge honor to be a strategic partner with the Chinese Media Group and the Esports World Cup Foundation with the establishment of the CMG National Institute for Esports Development, which marks another key sign of Beijing’s support for esports development,” chairman of VSPO, Asia’s biggest esports operator, Dino Ying said.
The ceremony fell on the same day as the International Olympic Committee announced that it has partnered with the National Olympic Committee (NOC) of Saudi Arabia to host the inaugural Olympic Esports Games 2025 in the Kingdom of Saudi Arabia. The Olympic Esports Games marks a milestone development for the esports industry and an exciting new chapter for Olympic history.
VSPO was also a partner for the Olympic Esports Week in Singapore last year, which paved the way for the creation of the Olympic Esports Games. VSPO is also an organizer for the esports series at the Asian Games in Hangzhou in 2023 and Jakarta in 2018.
About VSPO
Founded in 2016, VSPO is the largest esports operator in Asia, producing more than 4,000 matches every year that captivate an online fan base of over 800 million. With a global presence encompassing 14 office locations and 8 top-tier esports arenas, VSPO offers a comprehensive suite of esports services, including tournament organization, marketing solutions, community development, and more. At the same time, VSPO was an organizer for the esports series at the Asian Games in Hangzhou in 2023 and Jakarta in 2018.
Hello, health enthusiasts! My name is Kaitlin, and I’m here to provide you with some wellness tips to help you live your best life. The holiday week may have come and gone, but summer is still in high gear — and so is extreme heat. Before you pick out your outfit, check out our guide on how to dress on hot days. Plus, read up on how to have the best July, from celebrating the Summer Olympics to getting your eyes checked. (It is Healthy Vision Month, after all.)
As always, check the weather in your area — and your horoscope, if you’re so inclined. Then read up on the below health and wellness tips to keep your summer the best one yet.
A new study found that older women who experienced more gratitude had a 9% lower risk of death from any cause over three years. Fortunately, gratitude is an easy skill to practice for anyone. Try writing down what you’re thankful for in a gratitude journal each day — it will also help you become more mindful overall.
July 11 was National Polyphenol Day — but you should be including polyphenols in your diet year-round. Polyphenols are natural compounds found in plants, which have the power to potentially lower cancer risk, boost brain health and reduce inflammation. Berries, dark chocolate, green tea, red wine, apples and nuts like almonds and walnuts all have polyphenols in them, so you have plenty of opportunities to enjoy these good-for-you compounds.
🪑Mind your posture and incorporate micro-movements
We know that sitting all day is bad for your health — and sitting on the wrong chair all day, or in the wrong position, can cause major pain. Aim for a chair that has good lumbar support, which can help distribute your body weight more evenly — and don’t stress about maintaining a straight, perfect-posture position all day, which can actually lead to more pain. Instead, incorporate many “micro-movements” throughout your day (like crossing and uncrossing your legs, or shifting your weight) in order to stay comfortable.
Gut health is a major topic on social media — but in general, experts say we may be overly concerned with the so-called “healing” of our digestive systems. According to experts who spoke to Women’s Health, though, there are certain signs that you should get a literal gut check, like frequent bouts of diarrhea, constipation or bloating. Just make sure to consult your doctor — not your FYP.
The Mediterranean diet gets plenty of praise, but you may also want to try the Atlantic diet, which is inspired by the diets of the people living in northwest Spain and Portugal. While there’s plenty of overlap between the Mediterranean diet and the Atlantic diet (both love olive oil, for example!), the Atlantic diet proposes eating more seafood, dairy, lean meat and nuts, as well as carbs like potatoes and bread. (The Mediterranean diet’s carb of choice is pasta.)
Got acne? The Mediterranean diet might be your better bet, according to a new study, which found that the diet led to significant reductions in skin lesions for participants. Researchers think that the anti-inflammatory effects of the low-sugar, high-omega-3 diet could be the reason why.
This newly trendy food (which includes sardines, anchovies and mackerel) is shelf-stable, and comes with good-for-you nutrients like B12 and vitamin D, as well as minerals like calcium and selenium. Toss some tiny fish in your salad, or blend them into a pasta sauce for a rich umami flavor.
There’s a lot of buzz (pun intended) around vibration plates, with some people claiming that exercising on these platforms can improve bone density and increase muscle strength. Experts say they’re onto something: These plates make your muscles contract in an attempt to maintain balance, which can make your body work harder overall. Next time you see one of these shake machines at the gym, hop on and try some squats or arm circles.
Going to a party where you won’t know anyone? Saba Harouni Lurie, a licensed marriage and family therapist, gives helpful tips on how to feel more comfortable striking up conversations — like offering to assist the host.
A new study published in Nature Medicine found that swapping out saturated animal fats (like butter) for plant-based unsaturated fats (like olive oil, a major component of the Mediterranean diet) may lower your risk of developing conditions like cardiovascular disease and type 2 diabetes. So, next time you’re looking for a simple pasta dish, go for a drizzle of EVOO instead of butter and noodles.
New Mexico, often called the Land of Enchantment, is a stunning vacation destination, celebrated for its diverse landscapes and Native American, Spanish and Anglo-American cultural influences.
Before European colonization, the region was shaped by the traditions of Hispanic and Native American people.
Today, the state’s compelling history is a main attraction for visitors often awestruck by its rugged and varied terrain.
From the local food and art to the overall character, New Mexico reflects the convergence of cultures to define this unique state.
Another reason visitors come to New Mexico is the alluring landscapes, ranging from dry deserts to lush forests.
The rich history involving Native American, Hispanic and Anglo influences is reflected in the state’s art, architecture, festivals and cuisine.(Nextrecord Archives/Getty Images)
Many people often imagine red rocks, vast deserts and distinctive rock formations of the Southwest when they think of New Mexico.
What might surprise new visitors is the white sand dunes, river gorges and dense, evergreen woodlands included in the state’s natural diverse landscape.
Here are some of the top locations to put on your New Mexico itinerary:
Santa Fe, New Mexico, is the oldest capital city in the United States. Inhabited in 1607, it was officially settled between 1609 and 1610, according to the city’s official website. Originally established with European-style dwellings, the city is full of historical sites and experiences.
A visit to Sante Fe can include a trip to the historic Santa Fe Plaza, exploration of the oldest church in America and a visit to one of the many museums, such as the Georgia O’Keeffe Museum, where the 20th century artist’s love for Northern New Mexico and Santa Fe is on display.
Albuquerque’s rich history and resulting culture are reasons it is a popular city to visit.
Albuquerque was established in 1706, but the city was originally inhabited by Native Americans. Following its establishment, the city became an important trading center. Although Albuquerque has become an area known for its high-tech industry, its historical significance has been preserved.
For a unique experience, visitors can explore historical pueblo sites or attend events like the annual Albuquerque International Balloon Fiesta.(Joe Raedle/Newsmakers)
Beyond the historical significance of Albuquerque, the city attracts visitors with its family-friendly attractions, such as the Albuquerque International Balloon Fiesta, which is a yearly hot air balloon festival. Another activity that families visiting New Mexico can enjoy is a trip to the ABQ BioPark, where they can explore the zoo, botanic garden and aquarium.
Visitors of all ages can also enjoy a scenic ride on the Sandia Peak Tramway, North America’s longest aerial tram ride. For those not afraid of heights, the tram offers fresh mountain air and incredible panoramic views of New Mexico.
Taos is best known among ski enthusiasts. Located in the Sangre de Cristo Mountains near New Mexico’s high desert, the small town offers ski opportunities for those who enjoy the popular winter sport.
Taos is also a haven for the arts. The Taos art colony was founded in Taos, New Mexico, because of the creative culture of the Pueblo people. The area celebrated a diverse range of artistic mediums, including furniture and tin work.
Taos received a modern artistic makeover in the early 20th century, and there are more than 70 galleries in Taos, according to Taos.org.
Taos Pueblo in Taos, N.M., has been designated both a UNESCO World Heritage Site and a National Historic Landmark.(obert Alexander/Getty Images)
Taos is also home to the Taos Pueblo, a UNESCO World Heritage Site and one of the oldest inhabited sites in the country. For context, other UNESCO-recognized historical cultural landmarks include the Taj Mahal in India and the Grand Canyon in the United States. The pueblo features 1,000-year-old adobe homes that exemplify the early history of the village. Travelers to northern New Mexico are welcome to visit the pueblos.
The caverns of Carlsbad Caverns National Park in New Mexico, located in the Guadalupe Mountains, is a large underground system formed over 4 million years ago, according to the National Park Service (NPS). The park consists of more than 100 limestone caves formed through a complex geological process involving acid dissolving the Capitan limestone, according to the U.S. Geological Survey.
One of the most notable cave chambers in North America, because of its size by volume and ease of accessibility for visitors, is located in Carlsbad Caverns.
The Big Room is a 1.25-mile trail that takes around an hour and a half to walk, according to NPS.
White Sands is a national park in New Mexico. Originally designated as a national monument in 1933, it was redesignated as a national park in 2019, according to the NPS. The White Sands National Park preserves a large portion of the unique white gypsum sand dune field and the plants and animals that live there.
Not only is it a remarkable place to see, the park offers a full day’s worth of activities. After an exciting dune sledding adventure, families and friends can sit down for a relaxing picnic enjoying the tranquil views. The day can end with a sunset stroll around one-half mile long, according to the NPS.
New Mexico has a high altitude and dry climate. Visitors should remain hydrated, wear sunscreen and be prepared for temperature changes.(Robert Alexander/Getty Images)
What to know before your New Mexico visit
When considering when to visit the state, some ideal times are from May to October, when the temperatures are warm enough to enjoy hiking and other outdoor activities. Skiers can still enjoy the snow-capped mountains in the spring without the freezing temperatures, according to travelandleisure.com.
Winter months are ideal for travelers on a budget or those hoping to avoid the crowds of tourists.
No vacation is complete without partaking in the gastronomic culture of the location visited. New Mexico’s cuisine blends Native American, Spanish and Anglo dishes. The state’s signature dishes are reminiscent of Mexican and Tex-Mex cuisine with a distinctive flair. A main ingredient that sets New Mexico’s cuisine apart is chile, an ingredient indigenous to North America.
Visitors to New Mexico should take full advantage of the rich culture by exploring the activities and events available during their stay, such as those at museums, art galleries and historic locations.
Breana Scheckwitz is an SEO Editor at Fox News Digital.
TOKYO, July 14, 2024 /PRNewswire/ — KLab Inc., a leader in online mobile games, announced that the first puzzle game based on the hit TV animation series BLEACH, BLEACH Soul Puzzle, is set to be released in 2024. See the original press release (https://www.klab.com/en/press/) for more information.
KLab Inc., a leader in online mobile games, announced that the first puzzle game based on the hit TV animation series BLEACH, BLEACH Soul Puzzle, is set to be released in 2024.
Pre-orders and pre-registration are now being accepted on the App Store and Google Play.
A campaign will also be held where participants have the chance to receive an autograph from Ichigo Kurosaki’s voice actor, Masakazu Morita.
About BLEACH Soul Puzzle
This title is a match 3 puzzle game that features characters from the BLEACH TV Animation Series: Thousand-Year Blood War. With support provided for English and Japanese, BLEACH Soul Puzzle will be released worldwide in over 150 countries and regions including Japan.
