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URBAN SPORTS AND STREET ARTS MEET IN SINGAPORE AS PART OF A GLOBAL WARM-UP TO THE PARIS 2024 OLYMPIC GAMES

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The unique event, which is among the first global events created to build excitement for the upcoming Olympic Games, sees French and Singaporeans athletes and artists coming together to revitalise the iconic skate park in Singapore

SINGAPORE, May 24, 2024 /PRNewswire/ — In the lead up to the Paris 2024 Olympic Games, the Embassy of France in Singapore is organising a special two-day celebration of sports and arts aptly titled Artletics – making it among the first celebratory events organised around the world to drum up excitement for the global sports meet.

In collaboration with local partner Art Outreach and supported by the Singapore Tourism Board, the event happening on 25 and 26 May sees urban sports athletes and urban artists from both countries converging at the 18-year-old Somerset Skate Park to immerse Singaporeans in a joint showcase of their talents.

The event’s focus on urban sports gives a nod to the inclusion of the category into the upcoming Paris 2024 Olympic Games, which includes sports like BMX, skateboarding and breaking. It also runs parallel to the plans to transform the Place de la Concorde in Paris into an urban sports space. The unique collaboration also serves as a bridge between France and Singapore, deepening cultural ties through a shared passion for artistic expression and athleticism.

Ambassador of France to Singapore Her Excellency Minh-di Tang said, ‘Artletics embodies the spirit of street culture and celebrates artists and athletes striving for excellence, creativity and team spirit in the city where they leave lasting legacies and drive positive change in society. These core values pay homage to what the Olympic Games stand for, which France is hosting for the third time this year. Through Artletics, we want to showcase the best of French and Singaporean artistry, athleticism and sportsmanship, strengthening the cross-cultural partnerships our countries have enjoyed for many years.”

The transformed Somerset Skate Park in Singapore will host exhilarating showcases by urban sports athletes and practitioners from Singapore and France, including Max Berguin, the champion of the France Street Skateboard 2023 (Image courtesy of Embassy of France in Singapore)
The transformed Somerset Skate Park in Singapore will host exhilarating showcases by urban sports athletes and practitioners from Singapore and France, including Max Berguin, the champion of the France Street Skateboard 2023 (Image courtesy of Embassy of France in Singapore)

Somerset Skate Park transformed into a vibrant urban playground

Artletics caps off a month-long line up of programmes under the vOilah! France Singapore Festival – an annual cultural festival organised by the Embassy of France in Singapore to demonstrate French creativity and innovation through the power of cross-cultural collaborations.

In the spirit of enabling cultural exchanges, the Somerset Skate Park in the heart of Orchard Road is transformed into a dynamic space as orchestrated by urban artists from Singapore and France.

Three visual artists from Singapore – Zero, Spaz, and Simpleproblembeings – worked alongside French muralist Elsa Martino and graffiti artist Kekli to enliven the space by decorating the walls and the ramps of the skate park with vibrant designs. Supported by Singapore’s urban art collective RSCLS, these artists also will lead the public in engaging art jam sessions to partake in a collaboration of community artwork.

First to utilise the redecorated space are French skateboarding athlete Max Berguin, Champion of the France Street Skateboard 2023 and Singaporean urban sport communities in the field of skateboarding, breaking, BMX, bike trials, parkour and yo-yo who will be displaying their talents to spectators.

The event also features adrenaline-inducing urban sports showcases, opportunities for the public to take part in workshops conducted by local urban sports groups, as well as music sets in the evening by Singaporean DJs Kiat and Intriguant.

“Artletics is a vibrant celebration of the creative spirit that bridges French and Singaporean cultures through youth, urban sports and art,” said Mae Anderson, Chairman of Art Outreach. “We are thrilled to see French and Singaporean artists and skateboarders come together, transforming Somerset Skate Park into a collaborative canvas. We hope this event serves as a great opportunity for everyone to experience the power of art, athletics, while fostering a sense of belonging, inclusion and community spirit.”

Singapore's Somerset Skate Park will be transformed with artworks by Singaporean and French artists as part of Artletics - one of the first celebratory events globally to create excitement for the upcoming Paris 2024 Olympic Games (Image courtesy of Embassy of France in Singapore)
Singapore’s Somerset Skate Park will be transformed with artworks by Singaporean and French artists as part of Artletics – one of the first celebratory events globally to create excitement for the upcoming Paris 2024 Olympic Games (Image courtesy of Embassy of France in Singapore)

More details of the festival and the programme can be found at www.voilah.sg/artletics.

-END-

About vOilah! 2024

vOilah! 2024 returns from 25 April to 26 May 2024. Presented by the Embassy of France in Singapore, this year’s edition will focus on celebrating the dreams and passions of artists and athletes, bringing experiences that make life more vibrant through strong connections between the French and Singaporean communities.

This year, visitors can look forward to 19 programmes covering audiovisual arts, performing arts, visual arts, lifestyle, sports, education, science, music. With the support of more than 50 partners, vOilah! 2024 is a culmination of vibrant and dynamic experiences that will strengthen an appreciation of arts, culture and innovative collaborations between our countries.

For more information, visit www.voilah.sg/artletics/

About Art Outreach

Art Outreach, established in 2003, passionately promotes art appreciation and strengthens the local art ecosystem. We also empower practitioners through professional development support and an incubatory art space. Our year-round programmes, tailored to diverse audiences, include educational talks, art tours, exhibitions, and workshops, fostering a deeper understanding and appreciation of art and artists within the community. By supporting a wide range of artists and art shows, we actively promote plurality and advocacy within the arts, championing inclusivity and celebrating a rich tapestry of artistic expression. Art Outreach has been an IPC charity since inception, and has been a multiple-year recipient of the Commissioner of Charities governance award. We are led by a deeply committed board and nurture a dynamic and cohesive team culture.

For more information, please visit www.artoutreachsingapore.org/

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ASCO 2024 | Ascentage Pharma Releases Latest Results from Multiple Clinical Studies of Its Lead Drug Candidates

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SUZHOU, China and ROCKVILLE, Md., May 24, 2024 /PRNewswire/ — Ascentage Pharma (6855.HK), a global biopharmaceutical company engaged in developing novel therapies for cancer, chronic hepatitis B (CHB), and age-related diseases, announced today that its four abstracts selected for presentations at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting are now available on ASCO’s official website. These abstracts report on the company’s three lead drug candidates, including olverembatinib (HQP1351), the first and only China-approved third-generation BCR-ABL inhibitor; lisaftoclax (APG-2575), a BCL-2 selective inhibitor; and APG-2449, a FAK/ALK/ROS1 inhibitor.

Updated results from the four studies will be presented in Oral Reports or Posters at the ASCO Annual Meeting taking place on May 31 – June 4, 2024 in Chicago, IL. The ASCO Annual Meeting showcases the most cutting-edge research in clinical oncology and state-of-the-art advanced cancer therapies and is the world’s most influential and prominent scientific gathering of the clinical oncology community.

“It is our pleasure to present the latest data on our key drug candidates at the ASCO Annual Meeting for the seventh consecutive year,” said Dr. Yifan Zhai, Chief Medical Officer of Ascentage Pharma. “These encouraging results once again highlight Ascentage Pharma’s robust capabilities in global innovation and clinical development. Going forward, we will further expedite our clinical development programs globally in the hope of benefitting more patients in China and around the world as soon as possible.”

These four clinical studies to be presented at this year’s ASCO Annual Meeting are as follows:

Drug Candidates

Abstract Title

Abstract#

Format

Olverembatinib (HQP1351)

Updated efficacy results of olverembatinib (HQP1351) in patients with tyrosine kinase inhibitor (TKI)-resistant succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumor (GIST) and paraganglioma.

#11502

Oral

Report

Lisaftoclax

APG-2575

Safety and efficacy of lisaftoclax, a novel BCL-2 inhibitor, in combination with azacitidine in patients with treatment-naïve or relapsed or refractory acute myeloid leukemia.

#6541

Poster Presentation

Updated efficacy and safety results of BCL-2 inhibitor lisaftoclax (APG-2575) alone or combined with ibrutinib or rituximab in patients (pts) with Waldenström macroglobulinemia (WM).

#7078

Poster Presentation

APG-2449

Updated study results of novel FAK/ALK/ROS1 inhibitor APG-2449 in patients (pts) with non-small-cell lung cancer (NSCLC) resistant to second-generation ALK inhibitors.

#3124

Poster Presentation

The details of these abstracts are as follows:

Oral Report

Olverembatinib (HQP1351)

Updated efficacy results of olverembatinib (HQP1351) in patients with tyrosine kinase inhibitor (TKI)-resistant succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumor (GIST) and paraganglioma

Abstract#: 11502

Session Title: Sarcoma

Date and Time: June 3, 2024, Monday, 3:00 PM6:00 PM (Central Time)

First Author: Haibo Qiu, MD, PhD, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.

Highlights:

Background: SDH-deficient GIST is a rare type of GIST, mainly observed in the stomach of children, adolescents, and young adults under 30 years of age. No active targeted therapies have been identified in this subset of GIST. Olverembatinib, approved in China for the treatment of patients with chronic myeloid leukemia, has shown promising clinical efficacy in SDH-deficient GIST. In this abstract, the study reports updated efficacy data of olverembatinib in SDH-deficient GIST and preliminary efficacy data in paraganglioma, an SDH-deficient-related tumor.

Introduction: The aim of this study was to evaluate the safety and efficacy (per RECIST v1.1) of olverembatinib in patients with SDH-deficient GIST and other solid tumors. Olverembatinib was administered orally once every other day (QOD) in 28-day cycles.

Patient enrollment and methods: As of December 27, 2023, 26 patients with SDH-deficient GIST (confirmed by immunohistochemistry [IHC] assay) had received ≥1 dose of olverembatinib (median [range] age, 30 [13-56] years), and 25 of them had received 1-4 tyrosine kinase inhibitors (TKIs; 42.3% of patients received ≥3 TKIs). Olverembatinib was administered OQD in doses ranging from 30 to 50 mg (30 mg [n = 6]; 40 mg [n = 14]; 50 mg [n = 6]). This study also enrolled 6 patients with paraganglioma.

Efficacy results:

  • In the 26 patients with SDH-deficient GIST, the median (range) duration of treatment was 15.6 (1.8-42.3) months. 6 of those patients achieved partial responses (PR); another 18 patients achieved stable diseases (SD) lasting > 4 cycles. The clinical benefit rate (CBR, complete response [CR] + PR + SD > 4 cycles) was 92.3% (24/26) and the longest treatment duration was 40 months. After a median (range) follow-up of 17.0 (4.1-57.5) months, the median (range) progression-free survival (PFS) was 25.7 months (12.1-not reached [NR]).
  • Among the 6 patients with paraganglioma, 5 achieved SDs > 4 cycles, with a CBR of 83.3% and a median (range) PFS of 8.25 (1.87-NR) months.

Safety results: The adverse event profile was the same as previously reported (Qiu H, et al, J Clin Oncol 41:11540), with no newly emergent safety issues observed.

Conclusions: Olverembatinib was well tolerated. In patients with SDH-deficient GIST, olverembatinib demonstrated a CBR exceeding 90% and significantly prolonged the estimated median PFS, indicating the potential benefit of this treatment and providing a benchmark for future studies in this rare subtype of GIST.

Poster Presentations

Lisaftoclax (APG-2575)

Safety and efficacy of lisaftoclax, a novel BCL-2 inhibitor, in combination with azacitidine in patients with treatment-naïve or relapsed or refractory acute myeloid leukemia

Abstract#: 6541

Session Title: Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant

Date and Time: June 3, 2024, Monday, 9:00 AM12:00 PM (Central Time)

First Author: Huafeng Wang, MD, PhD, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Highlights:

Background and introduction: Early studies showed that lisaftoclax in combination with various agents can synergistically induce apoptosis in acute myeloid leukemia (AML). This poster presents follow-up safety and efficacy data from a Phase Ib/II study of lisaftoclax combined with azacitidine (AZA) in adults with AML.

Patient enrollment and methods:

  • This study enrolled elderly (≥75 years)/unfit treatment-naïve (TN) patients with AML who were intolerant of standard induction chemotherapies and patients (≥18 years) with relapsed/refractory (R/R) AML. Lisaftoclax (400/600/800 mg) was administered orally once daily in 28-day cycles. In the first treatment cycle, a daily ramp up schedule was used to prevent tumor lysis syndrome (TLS). AZA was administered once daily on D1-D7 at 75 mg/m2.
  • As of January 25, 2024, 76 patients with AML were enrolled, including 37 patients with R/R AML and 39 elderly/unfit patients with TN AML who were intolerant of standard induction chemotherapies. The median (range) age was 66 (20-81) years, and 61.8% of the patients were male.

Efficacy results:

  • In patients with R/R AML treated with lisaftoclax combined with AZA, the overall response rate ([ORR]=CR + CRi + morphologic leukemia-free state [MLFS] + PR) was 72.7%, the composite complete remission rate (CRc = CR + CRi) was 45.5%. In the 600 mg cohort (n=30), the median duration of treatment was 3.8 months, the ORR was 76.7%, the CRc was 50.0%, the median time to CRc was 2.5 months, the median PFS was 10.2 months, and the median overall survival (OS) was 14.7 months.
  • Among patients with TN AML treated with lisaftoclax combined with AZA, the ORR was 64.1%, the CRc was 51.3%. In the 600 mg cohort (n=29), the median duration of treatment was 3.3 months, the median time to CRc was 1.9 months. The median PFS was not reached.
  • 600 mg lisaftoclax combined with AZA was established as the recommended Phase II dose (RP2D).

Safety results: All patients treated with lisaftoclax combined with AZA reported treatment-emergent adverse events (TEAEs), with 89.5% experiencing Grade 3/4 TEAEs and 43.4% experiencing serious adverse events (SAEs). Common TEAEs included neutropenia (60.5%), thrombocytopenia (60.5%), diarrhea (42.1%), hypokalemia (40.8%), pyrexia (35.5%), and vomiting (30.3%). Grade ≥ 3 TEAEs reported in ≥ 10% of patients included neutropenia (57.9%), thrombocytopenia (50.0%), anemia (27.6%), pneumonia (17.1%), and febrile neutropenia (10.5%). No TLS was reported. The 30-/60-day mortality rates were 1.3% and 3.9%, respectively.

Conclusions: These data support a promising role for the new Bcl-2 inhibitor lisaftoclax combined with AZA for the treatment of elderly/unfit TN patients with AML intolerant of standard induction chemotherapies and patients with R/R AML, especially given a potentially favorable safety profile in terms of TLS, the incidence of neutropenic fever, and low early mortality. A Phase III randomized, double-blind study is being conducted to determine whether lisaftoclax combined with AZA improves the survival of elderly/unfit TN patients with AML intolerant of standard induction chemotherapies.

Updated efficacy and safety results of BCL-2 inhibitor lisaftoclax (APG-2575) alone or combined with ibrutinib or rituximab in patients (pts) with Waldenström macroglobulinemia (WM)

Abstract#: 7078

Session Title: Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia

Date and Time: June 3, 2024, Monday, 9:00 AM– 12:00 PM (Central Time)

First Author: Masa Lasica, MBBS, FRACP, FRCPA, St Vincent’s Hospital, Melbourne, Victoria, Australia.

Highlights:

Background: Lisaftoclax is a novel, oral, highly selective, potent Bcl-2 inhibitor. Lisaftoclax can overcome resistance to ibrutinib in ibrutinib-insensitive RPCI-WM1 models. In other non-Hodgkin lymphoma (NHL) models (including DOHH2 follicular lymphoma models and OCI-LY1 diffuse large B-cell lymphoma [DLBCL] models), lisaftoclax combined with ibrutinib has a strong synergistic antitumor effect.

Introduction: This is an open-label, multicenter, global Phase Ib/II study designed to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of lisaftoclax monotherapy or in combinations with agents such as ibrutinib/rituximab in patients with WM.

Patient enrollment and methods:

  • In this study, patients with WM were enrolled in 3 arms, including Arm A: lisaftoclax monotherapy in patients resistant or intolerant to prior treatment with Bruton’s tyrosine kinase inhibitors (BTKis); Arm B: lisaftoclax combined with ibrutinib in treatment-naïve patients with WM; and Arm C: lisaftoclax combined with rituximab in BTKi-naïve patients with relapsed/refractory WM.
  • Lisaftoclax was orally administered once daily in 28-day cycles. Lisaftoclax was gradually escalated from the starting dose of 400 mg to 1,200 mg. As of January 25, 2024, a total of 46 patients were enrolled in the study (Arm A [n=14] at doses of up to 1,000 mg; Arm B [n=24] at doses of up to 1,200 mg; Arm C [n=8] at doses of up to 800 mg).

Efficacy results:

  • The median (range) durations of treatment were 11 (1-28), 23.5 (1-34), and 11.5 (5-33) months for Arms A, B, and C, respectively.
  • The objective response rates (ORRs; PR, very good partial response [VGPR], CR) were 41.7%, 90.9%, and 37.5% for Arms A, B, and C, respectively.
  • In Arm A, patients with wild-type CXCR4 (n =7) had better overall response to lisaftoclax than the CXCR4mut group (n = 3).
  • In Arms B and C, no significant differences between patients with/without CXCR4mut were observed.

Safety results:

  • In Arm B, 1 dose-limiting toxicity (DLT, grade 3 clinical TLS), attributed to pre-existing renal impairment, occurred at 1,200 mg; and 1 grade 3 laboratory TLS, primarily attributed to dehydration and concomitant symptomatic therapies, occurred at 1,000 mg. Abnormal electrolytes was resolved without recurrence after 1 day of drug interruption.
  • Grade ≥ 3 lisaftoclax-related adverse events (AEs) included neutropenia (15.2%), thrombocytopenia (4.3%), decreased leukocytes (4.3%), TLS (4.3%), anemia (2.2%), weight loss (2.2%), and septic shock (2.2%).
  • Ventricular arrhythmia was not observed.
  • One patient required dose reduction because of neutropenia.
  • The maximum-tolerated dose (MTD) was not reached.
  • Lisaftoclax combined with ibrutinib showed a PK exposure comparable to lisaftoclax or ibrutinib alone, indicating no potential drug-drug interactions (DDIs).

Conclusions: Lisaftoclax alone and combined with ibrutinib or rituximab was well tolerated and demonstrated measurable effects in patients with treatment-naïve or BTKi-treatment-failed WM.

APG-2449

Updated study results of novel FAK/ALK/ROS1 inhibitor APG-2449 in patients (pts) with non-small-cell lung cancer (NSCLC) resistant to second-generation ALK inhibitors.

Abstract#: 3124

Session Title: Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology

Date and Time: June 1, 2024, Saturday, 9:00 AM12:00 PM (Central Time)

First Author: Yuxiang Ma, MD, PhD, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.

Highlights:

Background: ALK inhibitors increase FAK pathway gene expression in ALK+ NSCLC cell lines, with the highest induced expression in drug-tolerant persister cells. This suggests that FAK pathway activation is involved in the mechanism that leads to ALK TKI resistance in ALK+ NSCLC. APG-2449 is an orally active FAK inhibitor and a third-generation ALK/ROS1 TKI that has shown potent antitumor activity in preclinical models and clinical studies. This poster reports further safety and efficacy data of APG-2449.

Patient enrollment and methods:

  • This study comprises a dose-escalation portion and a dose-expansion portion. 1,200 mg daily (QD) was determined as the RP2D. There are two cohorts in the dose-expansion portion: Cohort 1 included patients with NSCLC who were resistant to second-generation ALK TKIs; Cohort 2 included patients with NSCLC who were ALK or ROS1 TKI naïve.
  • As of December 9, 2023, a total of 144 patients with NSCLC, mesothelioma, or ovarian cancer were treated with APG-2449 at doses ranging from 150 – 1,500 mg. The median (range) age of patients was 53 (21-78) years and 53.5% were female.

Efficacy results:

  • The ORRs of APG-2449 in patients with ROS1 and ALK TKI-naïve NSCLC (n=36) were 68.2% (15/22) and 78.6% (11/14), respectively. Of the 22 patients with NSCLC resistant to second-generation ALK inhibitors and without targetable bypass gene mutations (e.g., KRAS G12C, BRAF V600E), 9 achieved PRs (9/22; 40.9%). Among the patients treated with RP2D, 12 had brain metastasis at baseline, 9 of whom achieved intracranial PR, resulting in an intracranial ORR of 75.0%.
  • Biomarker analysis found that in patients with NSCLC that was resistant to second-generation ALK TKIs, PFS was correlated with phosphorylated FAK (pFAK) levels in the tumor tissue, suggesting that patients with higher pFAK levels were more likely to benefit from APG-2449.

Safety results: A total of 129 (89.6%) patients had treatment‑related adverse events (TRAEs), the most frequent of which were elevated serum creatinine (49.3%), increase in alanine aminotransferase (42.4%), increase in aspartate aminotransferase (36.1%); nausea (28.5%); vomiting (23.6%); diarrhea (22.9%); and decreased leukocyte count (22.2%). In all, 20 (13.9%) TRAEs were grade ≥ 3.

Conclusions: APG-2449 demonstrated preliminary efficacy in patients with NSCLC whose disease was TKI naïve and resistant to second-generation ALK inhibitors, especially in brain metastases. Biomarker analysis showed that high pFAK expression levels in baseline tumor tissue correlated with improved APG-2449 treatment responses in patients with NSCLC resistant to second-generation ALK TKIs.

*Olverembatinib is an investigational drug that has not been approved for any indication outside the Chinese mainland.

*Lisaftoclax and APG-2449 are investigational drugs that have not been approved in any country and region.

About Ascentage Pharma

Ascentage Pharma (6855.HK) is a globally focused biopharmaceutical company engaged in developing novel therapies for cancers, chronic hepatitis B, and age-related diseases. On October 28, 2019, Ascentage Pharma was listed on the Main Board of the Stock Exchange of Hong Kong Limited with the stock code 6855.HK.

Ascentage Pharma focuses on developing therapeutics that inhibit protein-protein interactions to restore apoptosis, or programmed cell death. The company has built a pipeline of 9 clinical drug candidates, including novel, highly potent Bcl-2, and dual Bcl-2/Bcl-xL inhibitors, as well as candidates aimed at IAP and MDM2-p53 pathways, and next-generation tyrosine kinase inhibitors (TKIs). Ascentage Pharma is also the only company in the world with active clinical programs targeting all three known classes of key apoptosis regulators. The company is conducting more than 40 Phase I/II clinical trials, including 5 global registrational phase III studies, in the US, Australia, Europe, and China. Ascentage Pharma has been designated for multiple Major National R&D Projects, including five Major New Drug Projects, one New Drug Incubator status, four Innovative Drug Programs, and one Major Project for the Prevention and Treatment of Infectious Diseases.

Olverembatinib, the company’s core drug candidate developed for the treatment of drug-resistant chronic myeloid leukemia (CML) and the company’s first approved product in China, has been granted Priority Review Designations and Breakthrough Therapy Designations by the Center for Drug Evaluation (CDE) of China National Medical Products Administration (NMPA). To date, the drug had been included into the China 2022 National Reimbursement Drug List (NRDL). Furthermore, olverembatinib has been granted an Orphan Drug Designation (ODD) and a Fast Track Designation (FTD) by the US FDA, and an Orphan Designation by the EMA of the EU. To date, Ascentage Pharma has obtained a total of 16 ODDs from the US FDA and 1 Orphan Designation from the EMA of the EU for 4 of the company’s investigational drug candidates.

Leveraging its robust R&D capabilities, Ascentage Pharma has built a portfolio of global intellectual property rights and entered into global partnerships with numerous renowned biotechnology and pharmaceutical companies and research institutes such as UNITY Biotechnology, MD Anderson Cancer Center, Mayo Clinic, Dana-Farber Cancer Institute, MSD, and AstraZeneca. The company has built a talented team with global experience in the discovery and development of innovative drugs and is setting up its world-class commercial manufacturing and Sales & Marketing teams. One pivotal aim of Ascentage Pharma is to continuously strengthen its R&D capabilities and accelerate its clinical development programs, in order to fulfil its mission of addressing unmet clinical needs in China and around the world for the benefit of more patients.

Forward-Looking Statements

The forward-looking statements made in this article relate only to the events or information as of the date on which the statements are made in this article. Except as required by law, Ascentage Pharma undertakes no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events, or otherwise, after the date on which the statements are made or to reflect the occurrence of unanticipated events. You should read this article completely and with the understanding that our actual future results or performance may be materially different from what we expect. In this article, statements of, or references to, our intentions or those of any of our Directors or our Company are made as of the date of this article. Any of these intentions may alter in light of future development.

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COP29 Unveils Accommodation Platform

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Portal Will Enable Participants and Attendees to Book Rooms for November Event in Baku

BAKU, Azerbaijan, May 24, 2024 /PRNewswire/ — Azerbaijan, the host of COP29, today unveiled its interactive accommodation portal, the system that will enable participants and attendees to book hotel rooms and other lodging for the United Nations Climate Change Conference being held in Baku in November.

COP29 Launch of accommodation platform
COP29 Launch of accommodation platform

In a press conference at the COP29 Office, Azada Huseynova, Deputy Chair of the State Tourism Agency of the Republic of Azerbaijan, said the accommodation system has been designed to ensure that a range of room types and locations will be available to people who want to attend the event.

The accommodation platform will be available for reservations https://cop29-accommodation.bnetwork.com from 17:00 today, on 23rd May, 2024.

“We will be ready to welcome the world to Baku. We have studied the experiences of previous COP host countries and how they approached their accommodation programs and have integrated some elements of those practices into our plans as COP host country,” Ms. Huseynova said. “We have put in place the infrastructure that will ensure that participants from around the world can make their accommodation booking in a smooth and speedy way.”

The State Tourism Agency is working with hotels, on-line accommodation marketplaces, and other residential and lodging locations in the city and region, to ensure that the event will be able to host the full complement of attendees comfortably and enjoyably.      

The lodging made available in the system today is the first phase of a comprehensive rollout. Further phases will release additional rooms at additional hotels and lodging facilities.

The hotels included in the platform have been selected on the basis of quality, location and transportation services that will be arranged for the event. The Agency audited more than 300 accommodation establishments, and approximately 200 have been classified and received a star rating. About 40 hotels that did not earn a star classification were given a period to improve facilities and performance before being re-audited.

Ms. Huseynova also provided details of a customer service training program being undertaken by the State Tourism Agency in advance of COP29. Approximately 2,000 employees from about 300 establishments in the cities of Baku and Sumgayit, and the wider Absheron region are participating.

In addition, the Agency plans to provide training and certification to 200 tourist guides, and training to a further 1,000 tourism volunteers, who will be assigned to hotels to support guests during COP29.

COP29 Launch of accommodation platform
COP29 Launch of accommodation platform
COP29 Launch of accommodation platform
COP29 Launch of accommodation platform
COP29 Launch of accommodation platform
COP29 Launch of accommodation platform

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I’m a pro baker, and these are the best Memorial Day kitchen deals — save up to 80% on knife sets, air fryers and more

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There’s something to be said about a 5 p.m. dinner reservation. No, it’s not prime time, but the restaurant’s usually less crowded, the food’s sometimes discounted and you’ll actually be able to digest your meal before bedtime. The same goes for holiday sales events; sure, it makes sense to assume that the best Memorial Day sales will drop on the main day itself, but we shopping editors know that there’s often a treasure trove of markdowns up for grabs in the quieter days leading up. You’ll have less competition to contend with, meaning the really good stuff likely won’t be sold out. I’m happy to report that this year’s Memorial Day kitchen deals take the cake — according to our price trackers, some all-time low prices are already popping up.

Now for some real talk: I’ll be the first to admit that not all “sales” are worth your time. I’d argue that the majority are underwhelming at best. That’s why I, a professional baker turned kitchen deals hunter, am sharing the ones I truly think are the cream of the crop. There’s a stunning Le Creuset Dutch oven marked down by $140, and its Lodge counterpart is just $70 (that’s the one I use). And if you’re looking for a Father’s Day gift for the griller in your life, the popular Meater kitchen thermometer is down to the best price I’ve seen. There’s also a bestselling Ninja Air Fryer for just $69, a Henckels knife set for over 60% off and so much more. So chop-chop — just like a blue plate special, these deals won’t last forever!

(Want even more savings? Check out our roundups of the best Amazon Memorial Day deals and the best Memorial Day deals overall.)

Walmart

‘Tis the season for enjoying tasty frozen treats, and this wildly popular appliance will satiate your sweet tooth in between trips to the ice cream truck. It churns out everything from ice cream and sorbet to milkshakes and more — just add your ingredients, freeze overnight, press a button and ta-da! Plus, you’ll be able to customize your creation with your favorite mix-ins. This is just about as low as I’ve seen it (it’s more expensive at Amazon!). 

“I am dairy-free, and finding a delicious dairy-free ice cream has been extremely difficult for me,” explained a (now) happy scooper. “Now I’m able to make my favorite flavors at home dairy-free! It’s super easy to use [and] cleans easily … my only complaint is it sounds like an airplane, it’s so loud.”

Check out our Ninja Creami review for more sweet revelations.

$149 at Walmart

Amazon

Le Creuset who? I cook with Lodge Dutch ovens at home, and this one is just the right size for a smaller household. The slick enameled interior cleans like a dream, while the sturdy cast iron offers excellent heat distribution and retention. Plus, it’s so pretty you won’t mind leaving it on the stove for everyone to admire. 

“Don’t tell my KitchenAid mixer, but I think I love this more,” joked a reviewer. “I’m Greek and cook a lot. I’ve used this for everything from pasta dishes like manestra to frying keftedes (meatballs) — [I’ve] even used [it] to bake bread! It’s a great item for one-pot meals. While it gets plenty hot because it’s cast iron, the enamel makes deglazing and cleaning a breeze. I use mostly silicone and wooden tools, but even with metal utensils, I haven’t had any chips. … Lodge is a great brand for those of us who can’t quite afford Le Creuset.”

Read my full Lodge Dutch oven review for more details. 

$70 at Amazon

Amazon

Of course, if “Le Creuset or bust” is the motto in your kitchen, you won’t do much better than this beauty that’s been marked down by $140. As durable as it is aesthetically pleasing, it’s coated in shock-resistant enamel that’s less prone to chipping, and its dome-shaped lid encourages heat circulation for even cooking. 

“Not as heavy as I expected, but still feels really premium,” shared a Dutch oven newbie. “Perfect size for two to six people. My first-ever bread came out perfect and was so easy to clean after. Super easy to cook with and I can’t wait to make some stews in it next.”

$280 at Amazon

Walmart

Bring your crispy, crunchy culinary dreams to life by way of this Walmart bestseller. It can roast, reheat and dehydrate, all in one machine — and with little to no oil. Plus, it’s compact but can fit up to 2 pounds of fries in its basket. Eat your heart out, Mickey D’s. (Psst: This price is better than Amazon’s!)

“This air fryer is top-notch,” raved a buyer. “I use it nearly every day. Better than heating my whole oven in summer. Reheats pizza slices in minutes. Perfect French fries. Crisps bread and rolls. Cleanup is a breeze. So glad I bought it.”

Check out our roundup of the best air fryers for 2024

$69 at Walmart

Amazon

Yes, this top-seller might technically be called a “meat” thermometer, but don’t underestimate its value when it comes to liquids and baked goods. The most accurate way to tell whether food is done cooking is by taking its temperature, and this gizmo presents a reading in seconds.

“I can’t believe I’ve gone so long without a good cooking thermometer,” wrote an impressed cook. “This thing works great, seems accurate. I like the magnet so I can keep it on my fridge for easy finding. I used it to make yogurt — takes all the guessing out of that process.”

$10 at Amazon

Amazon

Whether you know a dad who’s a grilling machine (Father’s Day is June 16!) or want your meat to come out perfectly every time, this popular pick is down to the lowest price I’ve seen. Pair it with your phone via an app and read the temperature that way, allowing you to focus on other tasks rather than babysitting your steak. 

“This probe is amazingly accurate,” raved a user. “The app supporting the probe is informative and predictive of when it will be done. That gives me time to prepare the side dishes so that they are all completed at the same time. I’ve told the Meater people that I may buy another two or three of these probes just in case they go out of business and I’m unable to get an eventual replacement!”

$70 at Amazon

Amazon

Rachael Ray, Ina Garten, Giada De Laurentiis and even Reese Witherspoon use Boos Block cutting boards, so you know you’re getting a quality piece. Having a large slab like this will allow you to prep multiple ingredients on the same surface, and it’s reversible in case you’d like to separate vegetables from meat. The indented handles on each side make for easier carrying too. 

“Terrific cutting board,” raved one shopper. “I have the tiniest kitchen in my apartment, and after watching some organizing videos, I realized I should make my small counter space completely covered by this sturdy cutting board. Why bother storing those dinky bamboo cutting boards when my complete surface is usable for food prep!”

$125 at Amazon

Amazon

Every kitchen needs a good pair of oven mitts, meaning those hole-filled ones in your drawer need to go. These top-sellers are heat-resistant up to 500°F, thanks to their silicone coatings — and not only that, their ribbed design offers better grip than cloth mitts, plus they’re water-resistant to protect your hands from hot splatters. They come in over 20 colors, though prices vary. (This pair is 60% off!)

“These oven mitts are a game-changer in my kitchen,” declared a buyer. “The ribbed silicone design provides a secure grip on hot pots and pans, giving me confidence when handling them. The soft inner lining is comfortable to wear and provides excellent heat protection. I appreciate that they are flexible and allow for easy movement of my hands, unlike some other oven mitts that can feel stiff and bulky. Plus, the set comes with two mitts, so I always have a backup when one is in the wash.”

$14 at Amazon

Amazon

Henckels has been crafting knives for over a century, so they know a thing or two about what makes a quality set. This bestselling collection is majorly marked down (over 60% off) and comes with just about every type of blade a home cook could need: a 3-inch paring knife, 5-inch serrated utility knife, 7-inch santoku knife, 8-inch chef’s knife and 8-inch bread knife. Also included: six 4.5-inch steak knives, a professional honing steel, kitchen shears and a hardwood knife block. Whew! 

“I needed a complete set of good knives,” explained a shopper. “After thorough research, I settled on these. The Henckels brand has an excellent reputation. They are well-balanced and each do the job as intended. They stay sharp longer than I expected. The wooden block looks nice and fits well on my countertop. This is a good investment that should last for many years!”

Check out our roundup of the best knives and knife sets for 2024 for more.

$125 at Amazon

Amazon

Not looking for a whole set? This affordable pair will have you slicing and dicing with ease. Also made by Henckels, this duo includes 5.5-inch and 7-inch santoku knives. Their shorter, fine-edged blades are suitable for precision chopping and thinly slicing while their lightweight construction allows for effortless movement. 

“Bought these to replace some of my older knives,” shared a content customer. “They work great and come sharp out of the box. I like the two sizes and they both fit in my hand well. Easy to grip and control while cutting.”

$25 at Amazon

Amazon

But wait: A 15-piece knife set for 40 bucks? Yes, chef! This one comes with a nifty self-sharpening block to keep the blades pointy, because we all know that trying to saw through a slippery tomato with a dull knife is about as aggravating as meal prep gets. Snag it before this 80% off deal gets chopped.

“I am loving this knife set, the sleek design takes up very little space,” shared a content customer. “It has a built-in sharpener, which is definitely a bonus and the white complements my mostly white kitchen beautifully. I could not be happier with this purchase.”

$40 at Amazon

Walmart

Starbucks spending getting a little out of control? You won’t miss your barista-made latte (or those insane lines) with this bestselling espresso maker in your arsenal. Just pop in your pod of choice and it’ll brew both coffee and espresso drinks in no time — you can even pour them over ice on those sweltering summer mornings. 

“My boyfriend enjoys drinking hot coffee while I enjoy hot and cold espresso drinks,” explained a fan. “This machine is good for the best of both worlds; I upgraded to this from a Keurig and I’ve never used a coffee machine more than I use this one. It’s genuinely good espresso — I don’t go to coffee shops anymore because I can get my fix at home.”

$127 at Walmart

Amazon

Hate having to drag out a cutting board every time you need to slice an onion? And does said onion make your eyes tear up with the sting of a hundred jellyfish? That’s why thousands of shoppers reach for this bestseller, which chops veggies into tiny, uniform pieces with just one push. And because everything falls into the attached tray, you’ll keep your counter clean too. 

“I love this … cuts down my chopping time by 80%,” gushed a user. “[It] comes with stuff you need to clean the grates! I have been using this almost daily, [the] whole family loves it … Many times I had chopped more than I needed … I just put the whole thing in the fridge … it has its own storage.”

Save $25 with Prime

$25 at Amazon

Amazon

It’s time to chuck all of your mismatched food storage containers and replace them with this heavily marked-down set. It comes with 12 round and rectangular containers, which are clear so you can easily see their contents. Since they’re made of borosilicate glass, the containers are dishwasher-, oven- and microwave-safe (just not the lids), and their airtight silicone seals help prevent leaks.

“I bought these for myself as I was tired of my plastic Tupperware staining and becoming dingy,” explained a fan. “The glass containers were exactly what I was looking for and wanted. … They are super easy to clean (straight in the dishwasher), and I would not hesitate to buy them again.”

Check out our roundup of the best food storage containers for more. 

Save $40 with coupon

$30 at Amazon

HexClad

Gordon Ramsay approves of this brand, and you know how particular the celebrity chef is. The pans’ hybrid construction combines the best qualities of stainless steel, cast iron and nonstick for a one-of-a-kind product that, according to Ramsay, “is highly versatile and cooks exceptionally well.” They’re made of aluminum sandwiched between stainless steel for expert heat conduction and distribution, and their nonstick interiors make them a breeze to clean. Plus, the signature hexagonal etching helps encourage browning. With this starter set, you’ll get the 12-inch, 10-inch and 8-inch Hybrid pans, plus lids for each. You’ll also get the 7-inch Hybrid pan as a free gift with your purchase. 

“These are the best pans I have used,” declared a home cook. “They are nonstick and cleanup is a breeze. I’ve used these for over a year, almost every day, and they are just like the day I unboxed them. I highly recommend these pans and plan to buy a set for each of my kids.”

Check out our roundup of the best pots, pans and cookware sets of 2024 for more. 

$400 at HexClad

Amazon

An 11-piece nonstick cookware set for 60 bucks? There’s gotta be a catch. Well, the only one I can think of is that there are just two detachable handles that clip onto every pot and pan in this collection — and that’s a good thing! Now you’ll be able to stack the pieces and save space in your cabinets. This top-seller comes with two frying pans, two saucepans, a sauté pan, two removable handles, two silicone lids and two fridge storage lids. 

“I got these in order to make some more space in my cabinets,” wrote a buyer. “These take up a quarter of the space my old pots and pans used. They work great on my glass stove top. They are so easy to clean and have not scratched, dented or stained!”

Save $60 with coupon

$60 at Amazon

Target

Double-duty appliances are always a boon for smaller kitchens — but a 10-in-1 gadget? Our cups runneth over! This pressure cooker and air fryer combo has functions that range from steaming and searing to broiling and even yogurt-making, and it’s large enough to hold a 4-pound chicken. Thanks for your service, full-size oven — you’re on hiatus until Thanksgiving. 

“This pressure cooker/air fryer is so user-friendly!” exclaimed a shopper. “It’s just a matter of which lid to use and an easy program button to push! I love it! I used to have to use two separate units to do what only one does now. Well made and lots of options.”

$100 at Target

QVC

You’ll feel like you have your own personal smoothie shop with this best-in-class blender. Boasting a 2.2-horsepower motor, it’ll effortlessly blitz up ice and frozen fruit, though you could also use it for whizzing up sauces or even grinding up meat. From soup to nuts (as in, homemade nut butters), this workhorse will level up your meal prep like no other — and this is the best price I’m seeing.

“Best blender I’ve ever owned!” raved a fan. “I had a Ninja, which is a good brand, but this is so much better! Easy to use and very easy to clean. My smoothies come out perfectly blended with no pulp or ice chunks. The soup setting is easy and makes perfect hot soup.”

$380 at QVC

Walmart

Of course, you don’t have to spend hundreds on a blender if you’ll be using it less frequently. Take this lovely appliance that comes from Drew Barrymore’s kitchen line: It costs about the same as five smoothies you’d get from a juice bar, but looks like a million bucks. And aesthetics aside, it has seven settings to choose from, whether you’d like a perfectly uniform mixture or want your gazpacho to maintain some texture.

“I use this every morning to make my breakfast shakes,” shared a shopper. “I use ice and a protein bar in my shake, and the blender handles both really well. And it’s so pretty on my counter!”

$30 at Walmart

Amazon

Getting whacked in the face by a rogue droplet of hot oil isn’t fun. According to the manufacturer, this bestselling splatter screen can prevent up to 99% of liquids from escaping your pan as you cook, meaning you’re much less likely to get burned. Your stovetop will also be spared from greasy messes. Plus, it’ll help keep odors from consuming your kitchen, and unlike a lid, it’ll still allow steam to be released. Its little feet let it rest on your counter with the mesh part elevated, making it a cute little cooling rack. You could also use it as a strainer.

“Love this product!” exclaimed one thrilled reviewer. “Not only does it keep oil from popping out of the pan and onto the surrounding area, but I haven’t had a splatter burn since I started using it. I can keep the guard on the pan and it doesn’t burn or rupture. It is easy to clean in the dishwasher as well, and holds its strength and shape during cleaning.”

$7 at Amazon

Walmart

Butterfingers, unite! Stainless steel mixing bowls are where it’s at for clumsy bakers like me, since they’re shatterproof. What I love about this set is that each bowl comes with a lid — that way, if you’re making, say, bread dough that needs to rise, you’ll have a cover for it without having to waste plastic wrap. Plus, you’ll be able to pop any leftovers right into the fridge. 

“They are so much lighter than my regular mixing bowls and so much easier to handle,” said a home baker. “I used to feel I was jeopardizing my life whenever I took my ceramic bowls down. I highly recommend.”

$19 at Walmart

Amazon

Ina Garten herself is a fan of this wildly popular and versatile pan, which is made of durable cast iron that’ll last for years. It comes pre-seasoned and can withstand heat from any cooktop — it can even be used over a fire. Nothing’s better when it comes to achieving the perfect sear on your meat — and I can say from personal experience that it makes the best pancakes too.

“It’s already seasoned and I love that!” wrote a Lodge loyalist. “It is my favorite pan now. It’s pretty, so I leave it sitting on my stove all the time. Nothing is sticking to it and it’s super easy to clean, has great heat distribution and is excellent quality. This will be passed down for generations.”

Check out my full Lodge Cast Iron Skillet review for more. 

$20 at Amazon

Amazon

Air frying is super convenient, until it’s time to clean the tray. Take some of the work out by sticking one of these BPA-free silicone liners in before you cook; then, toss them into the dishwasher once you’re done! So much easier than trying to scrape off caked-on residue. These fit air fryers with 3-5-quart capacities. 

“We make fries in the air fryer at least once a week,” shared a user. “Plain or seasoned fries are easy, but adding other toppings makes a mess in the air fryer and looks sloppy when lifted out with tongs. No more! Cheese fries, chili fries, the silicone liner keeps the air fryer clean and your food looking good.”

$7 at Amazon

Amazon

You’ll feel so high-tech using this sleek touchscreen toaster, but the reality is, it couldn’t be easier to operate. You’ll have a clear visual guide when it comes to choosing the doneness level of your toast, as well as images of the different types of foods you can heat up, from bagels and pastries to waffles and English muffins. The extra-wide slots can handle thicker slices of bread, because we all know carbs are the best food group. 

“Toasters aren’t often as good as they used to be,” lamented a reviewer. “I tried and returned two before I purchased my Whall. It toasts evenly, has multiple settings (including defrost) and looks good on the counter. The pop-up button is a nice feature too. It lets you check progress on items you haven’t toasted before. You won’t be disappointed.”

Save $41 with coupon

$50 at Amazon

Amazon

So, your outdoor space is too small for a grill, and you’d really like to avoid a house full of smoke — but you’re still craving those charred foods of summer. This indoor grill sears proteins and veggies like a champ, but its smoke control system means you won’t be breathing in soot while you cook. In addition to a grill plate, it comes with a flat-top griddle (smash burgers, anyone?) and you’ll be able to fit up to six steaks at a time on its roomy cooking surface. Bonus: It comes with a food thermometer for accurate results every time. 

“I honestly like meat and poultry grilled on this better than on my outdoor grill,” admitted a shopper. “I am able to control the temperature better. The meat is much juicier. It’s just easier to use and I’m not standing outside in the heat in the summer. I love the griddle function. Boneless chicken breast is so tender and delicious like this! I was stunned!”

Check out our roundup of the best grills of 2024 for more. 

$200 at Amazon

Amazon

The best meals are the ones you can make by tossing all of the ingredients into one cooking vessel, then setting and forgetting. That’s probably why the Instant Pot has become such a cult favorite — and this model, with its 10 functions in one, is so versatile, it just might become your most-used appliance. Make rice, sear chicken, bake bread … or heck, even whip up some cheesecake in it. You’ll be able to cook enough food to feed six people, so I’ll be awaiting my dinner party invitation. 

“I was somewhat skeptical about Instant Pots for a long time and then I finally caved and decided to get one,” shared a convert. “It’s one of the better kitchen investments I’ve ever made. Delicious pulled pork in an hour, easy one-pot meals and perfectly cooked rice without a rice cooker. It opens up so many possibilities for weeknight meals. One day I even brought it to the office for a food day and made fresh mac and cheese in the cafeteria.”

$120 at Amazon

Amazon

I love cookware with glass lids because they allow me to check on my food without letting out the steam that keeps things juicy. This stunner from Staub is made from sturdy cast iron and has a matte enamel interior to promote browning (i.e. flavor). Start it on the stovetop and move it into the oven to cook baked pastas, meats, casseroles, rice dishes — it would even be ideal for gooey cinnamon rolls. And it’s so pretty, it can be used as a serving vessel too.

“I have always wanted a Staub and was looking for a pan that could handle soups, light frying, braising and casseroles,” wrote a fan. “This is perfect. So perfect, I made Chex Mix in it. Yes, a chef somewhere in the world is rolling in his/her grave. Point is, it’s versatile and also impressive in design to carry a finished meal from stove/oven to table.”

$170 at Amazon

Wayfair

Ready to finally trade your mismatched dishes for a cohesive collection? I’m swooning over this matte set, which includes dinner plates, salad plates, bowls and mugs. Simple yet sleek, these pieces will enhance the presentation of your delicious meals without taking all the focus. They’re also dishwasher- and microwave-safe. 

“The service for four is perfect for my family, and the matte finish gives it a modern and elegant touch that elevates every meal,” shared an impressed customer. “Each piece is beautifully crafted with attention to detail, and the quality is immediately noticeable. The set includes everything needed … and each piece has proven to be both durable and practical for daily use.”

$38 at Wayfair

The reviews quoted above reflect the most recent versions at the time of publication.

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SALTO WECOSYSTEM Connects with Hospitality and Real Estate Experts at HoSkar Night Phnom Penh

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HO CHI MINH CITY, Vietnam, May 23, 2024 /PRNewswire/ — SALTO WECOSYSTEM, a leading provider of integrated access control solutions, is delighted to announce its participation in the highly anticipated HoSkar Night Phnom Penh event. This collaboration aims to showcase Salto’s innovative solutions tailored for the real estate and hospitality sectors and shares success stories contributed to hospitality property in Cambodia and the region.

HoSkar Night Phnom Penh is brought by WeHub, hosted by Savills Hotels and in partnership with Salto Wecosystem, a prominent coworking and innovation hub in the heart of Cambodia’s capital city. Scheduled to take place in the vibrant city of Phnom Penh on 29th May 2024, the event will bring together industry leaders, technology enthusiasts, and innovators to explore the latest trends and advancements in various sectors.

SALTO WECOSYSTEM Connects with Hospitality and Real Estate Experts at HoSkar Night Phnom Penh
SALTO WECOSYSTEM Connects with Hospitality and Real Estate Experts at HoSkar Night Phnom Penh

Salto’s participation at the event will feature the display of its latest access control and management systems with demo wire-free locks stand and artboards in a cozy gallery vibe to storytelling and showcasing most well-known project reference in Cambodia, which is a harmonious blend of technology, aesthetics, and sustainability. Their commitment to delivering security solutions aligns with luxury resorts’ vision of providing an unforgettable, eco-friendly experience for its guests. Attendees will have the opportunity to learn how Salto’s technologies can streamline operations, enhance security, and deliver personalized experiences for real estate and hospitality businesses.

“We are thrilled to be part of the HoSkar Night event in Phnom Penh and to partner with WeHub to enhance the guest access experience for every single property and project across Cambodia and the surrounding region,” said Don Dinh, General Director for Salto Wecosystem Vietnam, Cambodia & Laos.

Beyond showcasing its technologies, Salto Wecosystem is more than just a group of companies and individuals – it is a community born out of a common goal: to empower access, in every sense – access to places, experiences, and opportunities. The company believes that the industry still has a long way to go, and it wants to play an active role in the exciting journey ahead.

“The Cambodia hospitality and real estate market is evolving rapidly, driven by global trends, and increasing local living standards. Engaging with local and international experts is crucial for staying updated and sharing market knowledge. The HoSkar Night event is tailored to connect local and foreign experts in a vibrant, engaging event, creating a community of business-minded individuals.” said Mauro Gasparotti, Founder of WeHub. “We are delighted to have Salto Wecosystem as a partner for this event, bringing new technology and solutions to the hospitality & real estate sectors”.

For more information about Salto Wecosystem and its participation in HoSkar Night Phnom Penh, please visit SALTO WECOSYSTEM: Empowering smarter access

To learn more about the event and inquire to attend, please visit https://hoskarnight.com/register/. For further inquiries or information, please contact the event organizers at Thi@wehubyou.com.

About Salto Wecosystem:

Salto Wecosystem is a leading provider of smart access solutions, dedicated to empowering businesses and individuals with seamless, secure, and personalized access to more experiences and opportunities. With a mission to enrich lives by enabling smarter access, Salto is at the forefront of the evolving access control and management landscape, delivering innovative technologies that redefine the way we interact with the spaces and services around us.

Let’s stay connected @saltowecosystem

Instagram: https://www.instagram.com/saltowecosystem/

YouTube: https://www.youtube.com/@saltowecosystem

LinkedIn: https://www.linkedin.com/company/salto-wecosystem/

Hotline: (+84) 2873000027

About WeHub:

WeHub is one of the most vibrant hospitality and real estate communities in Vietnam and Southeast Asia. WeHub was founded with the vision to connect businesses, people and ideas. The platform offers the latest trends and insights while facilitating business connections within the real estate and hospitality industries through various activities, including Meet The Experts conferences (MTE), HoSkar Night networking events, SIF masterclasses, and WeTalk private meetings for lead generation.

Follow WeHub’s official channels at:

LinkedIn: https://shorturl.at/Rw9GA 

Facebook: https://shorturl.at/YKnlY 

Contact WeHub for event collaboration: Host@wehubyou.com.

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3 great American cities for history buffs and patriotic travelers this summer

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Memorial Day weekend is generally considered the unofficial kickoff of the summer season, which means backyard barbecues, baseball games, beach trips and road trips to capture the patriotism of our great nation — as well as time to honor and remember those who gave their lives for our country. 

Summer offers a unique opportunity to travel with children or grandchildren and introduce them to important history lessons across the U.S. 

If you’re a history buff or want to share significant adventures with your family or friends, three American cities offer a blend of historic sites, museums and American tributes and national treasures.

JOHN WAYNE’S LIFELONG LEADING ROLE AS AMERICAN PATRIOT CELEBRATED AT FORT WORTH MUSEUM 

Leslie Carbone, a travel blogger at Sancerres at Sunset and based in Virginia, said that Colonial Williamsburg — the first location listed below — “is the world’s largest living history museum. It’s a place everyone who loves America should visit at least once,” she told Fox News Digital.

These three locations can foster learning opportunities and leisurely history lessons — and create memories for a lifetime. Read on for more details. 

1. Williamsburg, Virginia 

When you plan a visit to Williamsburg, you learn about the history of America, plus you’re surrounded by it.

Spring is a wonderful time to visit, said Carbone. “The weather is pleasant, the gardens are blooming, and the crowds are still manageable,” the travel blogger said. 

Williamsburg was the first planned city in America, founded in 1699 as the capital of the Virginia Colony. Today, you can explore the streets of a living history museum portrayed by Colonial Williamsburg. 

Governor's Palace in Colonial Williamsburg, VA

The historic Governor’s Palace is shown at Colonial Williamsburg, Virginia. (iStock)

While there, you can discover historic reenactments, archeological digs, historical taverns and enriching museums. 

Also, carve out time to stroll through the iconic shops of the noteworthy Merchants Square — and venture beyond Colonial Williamsburg to the enjoyable Williamsburg Tasting Trail, where you can enjoy standout craft beers, local wines and meads, plus distilled spirits.

CONSTRUCTION PROJECT IN VIRGINIA LEADS TO SURPRISING REVOLUTIONARY WAR-ERA DISCOVERY 

After a day of history lessons, settle in at the Williamsburg Lodge, Autograph Collection — which offers southern elegance and the furnishings of colonial times. 

While you step back in time during your travels, some culinary spots to try include Traditions in the Williamsburg Lodge or the city’s famous Cheese Shop. 

The Secrets and Untold Stories of Williamsburg Tour tells the true story of Americans that helped found our country.

For a history-centric dinner experience, consider Kings Arm Tavern, a “refined chophouse experience,” as its website notes. 

Also, take a tour of the historic First Baptist Church of Williamsburg, organized by Baptists in 1781 under Rev. Gowan Pamphlet, an enslaved man in Williamsburg.  

Another can’t miss is the Secrets and Untold Stories of Williamsburg Tour, the true story of Americans that helped found our country.

2. St. Augustine, Florida 

As the oldest city in the United States, this coastal location in northeastern Florida is a history lover’s pick.

The city boasts attractions such as military forts, castles, charming lighthouses, scenic nature trails and more. Be sure to visit museums, embark on scary ghost tours or participate in historical reenactments. 

Memorial Presbyterian Church in St. Augustine

Memorial Presbyterian Church in St. Augustine, Florida, which “is a thriving and multigenerational congregation … committed to Christian unity amid diversity,” its website says.  (Jeffrey Greenberg/Universal Images Group via Getty Images)

For history buffs, stop by Castillo de San Marcos, a fortress constructed by the Spanish between 1672 and 1695. 

It’s the oldest masonry fort in the continental United States, according to Visit Florida.

Then, meander through St. Augustine Lighthouse & Maritime Museum, an iconic lighthouse built in 1874 overlooking the Atlantic Ocean. 

You’ll learn about maritime heritage and the lives of the region’s lighthouse keepers. 

Here, you’ll learn about maritime heritage and the lives of the region’s lighthouse keepers. You can even ascend to the top and capture breathtaking views. 

ST. AUGUSTINE: EXPLORING FLORIDA’S LITTLE-KNOWN PARADISE 

Tim Schmidt, a Florida-based travel expert and author, told Fox News Digital that St. Augustine is a hidden destination for history lovers. 

“I live in South Florida, so I’m lucky enough to have visited this incredible city many times. There’s nowhere else in the U.S. that makes you feel like you’ve stepped right into the past quite like St. Augustine,” said Schmidt, who runs AllWorld.com

“There’s nowhere else in the U.S. that makes you feel like you’ve stepped right into the past quite like St. Augustine.”

Schmidt said he discovers new things each time he visits. 

“Every time I wander through the pedestrian-friendly historic district, with buildings dating back to the 1700s, I’m blown away by the sense that I’ve been transported back in time. You don’t just read about history here — you can reach out and touch it.” 

Bridge of Lions

The regal Bridge of Lions crosses Matanzas Bay from downtown St. Augustine. The town is filled with many historic buildings as the first settlement in the U.S. by Spaniards on the Florida coast. (Nik Wheeler/Corbis via Getty Images)

Be sure to plan time for the Cathedral Basilica of St. Augustine, considered the oldest Catholic parish in the United States, per Visit Florida. 

To get your steps in, stroll down St. George Street, a pedestrian thoroughfare in the heart of St. Augustine’s historic district, featuring shops and restaurants. 

For folklore beyond history, visit the Fountain of Youth Archaeological Park, which — according to legend — Spanish explorer Juan Ponce de León discovered the Fountain of Youth in St. Augustine in 1513. 

St. Augustine, Florida

An aerial view of historic St. Augustine, Florida. “You don’t just read about history here — you can reach out and touch it.”  (iStock)

For an enjoyable dining experience, try the Raintree Restaurant, Salt Life Food Shack or St. Augustine Seafood Company. 

When making travel plans, Rodeway Stay Inn is conveniently located within walking distance of some of St. Augustine’s renowned historical landmarks.

3. Independence, Missouri  

This midwestern destination is best known for being the home of President Harry S. Truman

While in town, pay a visit to the Harry S. Truman Presidential Library and Museum, which takes an in-depth look at his life and legacy. 

Harry S. Truman

Harry S. Truman (1884-1972) served as 33rd president of the United States.  (MPI/Getty Images)

Recently renovated in 2020, the site is also on the U.S. Civil Rights Trail, as Truman desegregated the United States military, according to the Missouri Tourism Office.

In addition, the city of Independence curated a Truman Historic Walking Trail to showcase locations and landmarks significant to the president. 

Independence was a starting point for thousands of American pioneers as they headed west on the Oregon, California and Santa Fe trails. 

“Independence is a great vacation destination for history buffs,” said Katie Blake, spokesperson with Missouri’s Division of Tourism. “It was hugely important to American pioneers and President Harry S. Truman once considered it the ‘center of the world.’ Its rich history is still evident today in its fascinating museums and landmarks.”

MISSOURI MUSEUM ACHIEVES WORLD RECORD FOR LARGEST GATHERING OF PEOPLE WITH UNDERWEAR ON THEIR HEADS 

Another site worth visiting is the Vaile Mansion, built in 1881. It was once known as “the most princely house and the most comfortable home in the entire west,” according to the Kansas City Times in 1882. 

Independence, Missouri

Independence, Missouri, on June 16, 2023. Afternoon sunlight shines on the historic core of downtown Independence. (iStock)

Independence is also known as the “Queen City of the Trails” because it was a starting point for thousands of American pioneers as they headed west on the Oregon, California, and Santa Fe trails. 

Visitors to Independence can learn about this part of the city’s history at National Frontier Trails Museum and Pioneer Trails Adventures, a guided tour on a mule-drawn covered wagon.

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Another point of interest is the Englewood Station Arts District, with charming shops, art galleries, restaurants and more. 

A few restaurants to consider are Vivilore, featuring American cuisine using locally sourced ingredients; Gates BBQ, a famous barbecue spot in Kansas City that has expanded into Independence; and Courthouse Exchange, a historic pub.

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Two lodging options for an Independence getaway are the Stoney Creek Hotel and the Holiday Inn Express & Suites Independence. 

For more Lifestyle articles, visit www.foxnews.com/lifestyle.

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Revolutionising Cardiac Care at Pantai Hospital Kuala Lumpur

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Advanced TAVI Procedure on Patient with Severe Aortic Stenosis

KUALA LUMPUR, Malaysia, May 23, 2024 /PRNewswire/ — Pantai Hospital Kuala Lumpur (PHKL), a leader in medical excellence and patient care, has achieved another significant medical milestone with the successful launch of its Transcatheter Aortic Valve Implantation (TAVI) program. TAVI is a minimally invasive procedure designed to replace a narrowed aortic valve that does not open properly. It is typically performed through a small incision in the groin, using a catheter to implant a new valve under x-ray guidance. The complex procedure is performed by a TAVI team led by PHKL’s Senior Consultant Cardiologist Dr. Yee Kok Meng on patients suffering from severe aortic stenosis, a condition in which the aortic valve narrows and impedes blood flow from the heart to the body.

Dr. Yee Kok Meng, Consultant Cardiologist (5th from the left), and Dr. Tan Kok Leng, Consultant Cardiologist (4th from the left), pictured with the cath lab team
Dr. Yee Kok Meng, Consultant Cardiologist (5th from the left), and Dr. Tan Kok Leng, Consultant Cardiologist (4th from the left), pictured with the cath lab team

“Traditionally, these very sick heart patients were treated surgically by replacing the damaged heart valve with an artificial valve via open heart surgery. However such operations especially in the elderly population or those with multiple comorbidities may be very high risk. Now with TAVI, we are able to offer such patients an alternative approach which is both minimally invasive and much safer” said Dr Yee.

“At Pantai Hospital Kuala Lumpur, I am especially glad we are able to ramp up the TAVI program this year thanks to the support of the PHKL hospital management and all the staff involved. Due to the complexity of the procedure, TAVI requires a teamwork approach, and to this end PHKL has really provided all the support required to build up a dedicated TAVI team, which I think is crucial to ensure that the excellent results in terms of patient care and clinical outcomes are maintained,” added Dr Yee. Over the past month, two patients diagnosed with critical aortic stenosis, including an 83-year-old gentleman from Ipoh, and a 69 year-old Indonesian recovering from a recent stroke underwent TAVI successfully. Both patients were discharged home within 48 hours of the procedure.

The Heart Centre at Pantai Hospital Kuala Lumpur has been at the forefront of treating complex heart conditions with cutting-edge technologies. This successful procedure not only represents a personal victory for the patient and Dr. Yee but also sets a benchmark for cardiac care standards nationwide.

To ensure the health of your heart continues to play the right rhythms, PHKL emphasises the importance of early detection and preventive measures. PHKL’s Heart Screening Package offers various assessments tailored to meet individual needs and lifestyles. From stress tests and echocardiograms to cardiac CT heart scans, our cardiologists are equipped to detect potential heart issues early and to ensure your heart is performing at its best.

“The success of such advanced procedures at PHKL is a testament to the expertise and dedication of our medical teams and their relentless pursuit of excellence in healthcare,” said Erica Lam, Chief Executive Officer of Pantai Hospital Kuala Lumpur. “We are proud to provide our patients with access to some of the most sophisticated treatment options available in the world right here in Malaysia.”

Pantai Hospital Kuala Lumpur remains dedicated to enhancing patient care through innovation and expertise, contributing significantly to the advancements in the medical field, particularly in the treatment of cardiovascular diseases.

For more information about PHKL Heart Screening Package, please visit Pantai Hospital Kuala Lumpur’s website: www.pantai.com.my/kuala-lumpur or visit Pantai Hospital Kuala Lumpur for a consultation and find out more about how you can stay ahead of heart disease.

Dr. Yee Kok Meng, Consultant Cardiologist
MBChB (Edin), MD (Cardiology, UK), M C P (UK), FACC (USA)

Dr Yee is a Senior Consultant Cardiologist at Pantai Hospital Kuala Lumpur since 2005, and has over 20 years of clinical experience as an Interventional Cardiologist. He obtained his degree in Internal Medicine at the University of Edinburgh, UK in 1993. He subsequently completed his training and specialised in Cardiology at Cambridge University in 2001. He was then offered a fellowship in Interventional Cardiology by the University of Toronto, Canada. Based at the Toronto General Hospital, Dr Yee gained vast experience in all aspects of interventional cardiology procedures. He subsequently returned to Malaysia in August 2002 Dr Yee has contributed significantly to the field of cardiology and has published widely in respected scientific journals. In 2002, the University of Edinburgh awarded Dr Yee the postgraduate MD doctorate in Cardiology with distinction. He has vast experience in a wide range of interventional procedures and performs most of his cases via the transradial route. He is also experienced with the use of various adjunctive devices and therapies such as rotational atherectomy, intravascular ultrasound (IVUS), OCT and coronary doppler wire (Pressure Wire).

About Pantai Hospital Kuala Lumpur
For 5 decades now, Pantai Hospital Kuala Lumpur (PHKL) has remained the heartbeat of Kuala Lumpur, steadfastly dedicated to delivering exceptional care and accessible cutting-edge technology to patients from all walks of life. Our journey began in 1974, with just 68 beds and a team of 20 medical specialists. Fast forward to the present day, we stand as a healthcare icon, operating 380 beds and home to over 200 consultants, each specialising in diverse medical and surgical disciplines.

At Pantai Hospital Kuala Lumpur, we are unwavering in our commitment to provide quality healthcare services while fostering clinical research and trials. We take pride in championing clinical excellence, service quality, and operational efficiency. Our pursuit of excellence has earned us accreditations from the Malaysian Society for Quality in Health (MSQH) and the Joint Commission International (JCI). Additionally, we are honoured to hold certification as a Baby Friendly Hospital and a preferred hospital in Malaysia by the World Health Organization (WHO).

As we celebrate our 50th anniversary, Pantai Hospital Kuala Lumpur reaffirms its role as a pillar of the city, offering world-class healthcare services, innovative treatments, and a legacy of excellence.

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MGM Resorts CEO Bill Hornbuckle talks Las Vegas’ travel boom

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Hosted by Brian Sullivan, “Last Call” is a fast-paced, entertaining business show that explores the intersection of money, culture and policy. Tune in Monday through Friday at 7 p.m. ET on CNBC.

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‘No Botox, no peels, no fillers’: Salma Hayek’s go-to ingredient for ageless skin is in this cream, now just $9

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Imagine being Salma Hayek — an award-winning actress and film producer, and a bonafide beauty icon. A red-carpet regular season after season, the 57-year-old never fails to blow us away, thanks to her seemingly ageless beauty. Wondering what the secret is behind her gorgeous complexion? The screen queen credits one buzzy ingredient in this cream for her glowing skin. You don’t have to have a movie star’s salary to bring home some for yourself: You can snag a jar now at Amazon while it’s on sale for just $9.

Amazon

This night cream contains Salma Hayek’s secret weapon skin-care ingredient for youthful-looking skin.

$9 at Amazon

While the Del Indio Papago Night Cream has gone on sale off and on over the last few months, this is the lowest price it’s been since Black Friday. Plus, $10 is a good price for a solid anti-aging regimen when you consider alternative methods.

Hayek has been steaming up the silver screen for nearly 30 years, but take one look at her youthful complexion and you’d think she was still an ingénue. There’s no magic behind her flawless skin, just the bark of a tree, found in this cream.

“I use an ingredient called Tepezcohuite that’s used in Mexico for burn victims because it completely regenerates the skin,” Hayek told Elle. “Some of the ingredients, when I took them to the American labs, they were like, ‘Oh my God! How come nobody is using this?’ This is why I have no Botox, no peels, no fillers.”

The Tepezcohuite tree is often called the “Mexican skin tree” because its bark is known to help regenerate skin and hair. As a testament to that, it was used to treat hundreds of thousands of burn victims in an earthquake and a gas explosion in Mexico in the 1980s when no medical supplies were available.

Not many American companies have caught on. Yahoo’s senior beauty editor, Jennifer Romolini, tested out Del Indio Papago Night Cream and reported softer skin, though she found another product with an even higher concentration of Tepezcohuite that’s possibly more effective on wrinkles.

Salma Hayek at a red carpet event

Could this Mexican cream make your skin look as timeless as Hayek’s? (Getty)

More than 4,000 Amazon shoppers give the Del Indio Papago Night Cream a perfect, five-star rating.

“I read the Salma Hayek article and decided to give it a go,” a reviewer said. “I have ridiculously picky skin (rosacea, sensitivities, etc.), and I don’t get my hopes up, as most things I try either irritate my skin or cause breakouts. I have sun damage, fine lines and menopausal acne. Basically, I never know what I’ll see when I look in the mirror. I’ve used this for three weeks, and so far, so good. No irritation, my skin is calm and hydrated, and best of all, no acne.”

“In all of my decades of trying skin care products, Tepezcohuite has been the most transformative product I have ever used,” declared an excited shopper. “In just a week’s worth of use, morning and night, I see a noticeable improvement in my skin’s tone, feel and texture. My 67-year-old skin glows again for the first time in decades.”

One five-star reviewer reported: “I get the hype. It is an excellent moisturizer. My skin feels smooth and hydrated. Small lines are less noticeable.”

“When I bought this cream, I didn’t know anything about it,” related an enthusiastic user. “I was pleasantly surprised at how it made my skin feel and the quality of the product. I will be 70 years old this month, and my skin looks 20 years younger.”

Some reviewers mention that the cream does have a natural scent, but say that it doesn’t bother them

“It’s super thick and feels great on my skin,” said one customer, adding: “It definitely smells like mimosa trees.”

“I’ve only been using it for a month, but I’m finally seeing a refinement of deep forehead deep lines,” said one four-star shopper. “My couple of complaints are the smell — unpleasant and medicinal. It’s also ‘gloppy’ to apply. However, the price is very nice. I have ultra sensitive skin and have had no issues with Del Indio.”

“The smell is a little intense but it doesn’t linger,” added another.

If you’re after the full 24-hour experience of this skin cream, Del Indio Papago makes a lighter-weight version for daytime use.

Amazon

This daytime cream contains Tepezcohuite powder, collagen and vitamin E.

$10 at Amazon

And if you’re interested in Tepezcohuite, we recommend trying out some other products containing the ingredient:

Amazon

“A higher concentration of [Tepezcohuite], plus a more natural formula at the same price point make this serum from Imagine Dermatology an obvious Del Indio Papago alternative,” wrote our Senior Beauty Editor, Jennifer Romolini. 

$16 at Amazon

Amazon

If you’d like to go full Tepezcohuite with Del Indio Papago, you can wash up with their bar soap too!

$8 at Amazon

The reviews quoted above reflect the most recent versions at the time of publication.

If you have Amazon Prime, you’ll get free shipping, of course. Not yet a member? No problem. You can sign up for your free 30-day trial here. (And by the way, those without Prime still get free shipping on orders of $25 or more.)

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GIGABYTE Showcases AI and User-Friendly Innovative Technology at COMPUTEX 2024

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TAIPEI, May 22, 2024 /PRNewswire/ — GIGABYTE, the world’s leading computer brand, is poised to captivate audiences at this year’s COMPUTEX with its latest offerings. From user-friendly designs to groundbreaking advancements in AI, visitors can expect a truly immersive experience across GIGABYTE and AORUS product lines such as motherboards, graphics cards, gaming monitors, and gaming laptops. As the world enters a new era of AI, GIGABYTE’s presence at COMPUTEX hints at exciting developments in the realm of AI, promising visitors a glimpse into the future of computing.

GIGABYTE Showcases AI and User-Friendly Innovative Technology at COMPUTEX 2024
GIGABYTE Showcases AI and User-Friendly Innovative Technology at COMPUTEX 2024

GIGABYTE will showcase cutting-edge features across its product lineup at COMPUTEX 2024. The AI Laptops including AORUS 17X and AORUS 16X steal the spotlight with the exclusive GIGABYTE AI Nexus, featuring three functions including AI Boost, enhancing performance as per specific scenarios, AI Generator for quick startups with generative AI utilities, and AI Power Gear that intelligently conserves battery life by optimizing power consumption. Additionally, the GIGABYTE GeForce RTX 40 SUPER series graphics cards are engineered to provide intense gaming and reliable AI computing power across a diverse range of applications. Complementing these advancements, the OLED Monitor series such as AORUS CO49DQ, integrates AI algorithms to introduce OLED CARE, including six key features designed to minimize burn-in risks on OLED screens and extend the screen’s lifespan.

In terms of user-friendly designs, GIGABYTE presents innovations like the EZ-Latch and Stealth Design on motherboards, streamlining PC assembly with quick and convenient installations while ensuring a clean appearance through efficient cable management. The LCD Edge View across various components like AORUS GeForce RTX 4080 SUPER MASTER enables real-time monitoring of PC performance and customizable display options. Furthermore, the GIGABYTE Arm Edition gaming monitors are equipped with ergonomic monitor mounts designed to cater to various usage environments from PC gaming, console gaming, to even streaming media, realizing the true 4K entertainment. Within the GIGABYTE OLED Gaming Monitor series, the Tactical Switch feature optimizes gaming by instant switching to a 24-inch size, 1080p resolution with a single click, specifically designed for first-person shooter games.

Additionally, GIGABYTE is proud to showcase multiple Red Dot 2024 award-winning products, including the Z790 AORUS XTREME X, Z790 AORUS MASTER X, Z790 AORUS PRO X, X670E AORUS PRO X motherboards, AORUS FO32U2P, GIGABYTE MO34WQC2 gaming monitors, and AORUS C400 GLASS gaming chassis. For more information, please visit the official GIGABYTE website at: https://bit.ly/GIGABYTE_COMPUTEX_2024

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